Abstract
Both enantiomers of 6-methyl-e-caprolactone (6-MeCL) are obtained in high enantiomeric excess by the combination of an enzymatic ring opening of racemic 6-methyl-e-caprolactone and subsequent enzymatic ring closure. Immobilized Candida antarctica lipase B (Novozym 435) was selected as the biocatalyst for both the ring-opening and the ring-closing reaction. This route provides ready access to enantiopure (S)-6-MeCL (ee = 99.6%) and (R)-6-MeCL (ee = 98.8%).
Original language | English |
---|---|
Pages (from-to) | 787-790 |
Journal | Tetrahedron |
Volume | 18 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2007 |