• Het Kranenveld, Helix (STO 4.33)



  • P.O. Box 513, Helix (STO 4.33)

    5600 MB Eindhoven


Organization profile

Introduction / mission

How far can we push chemical self-assembly? Bridging the gap between life sciences and materials science, using organic chemistry and polymer chemistry. 

Highlighted phrase

Exploration of supramolecular systems and materials

Organisational profile

At the Macro Organic Chemistry group we educate young students to become independent scientists and make them experienced researchers in the design, synthesis, characterization and possible applications of complex molecular systems with unconventional properties. Our research addresses the challenging question “How far can we push chemical self-assembly?”. This ranges from detailed mechanistic (kinetic) investigations on the self-assembly processes of various molecular structures (e.g. the formation of ordered arrays, under thermodynamic control as well as through kinetic experiments) to the design, non-covalent synthesis and use of artificial mimics of enzymes and extracellular matrices. Our group is part of the overarching research group for Molecular Science and Technology.

From the start in 1991, our research has been focused on the design, synthesis, characterization and possible applications of new functional molecular architectures. Over the years we have worked on dendrimers, semi-conducting oligomers/polymers and several supramolecular units, with chirality as a muse. In the course of time, our focus has shifted towards the synthesis and study of complex molecular systems and in 2007 our group became the founding father of the Institute of Complex Molecular Systems (ICMS) at TU/e. More recently, a renewed interest in functional supramolecular materials for electronics and biomedical engineering has underpinned the relevance of our knowledge in the design and synthesis of molecular units that self-assemble in a controlled way, producing materials ordered at the mesoscale. 

In our current research we aim at closing the gap between organic chemistry, polymer chemistry and chemical biology by applying well-controlled supramolecular chemistry protocols. Central to this is our concept of multi-step non-covalent synthesis of molecular systems, using well-defined small and large molecules. We thus synthesize and study novel artificial molecular systems where the position of all molecules in the system can be controlled with respect to time and space. To arrive at dynamic functionalties of these molecular systems, we investigate the response to external stimuli both experimentally and theoretically.

Fingerprint Dive into the research topics where Macro-Organic Chemistry is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

Polymers Chemical Compounds
Self assembly Chemical Compounds
Hydrogen bonds Chemical Compounds
Molecules Chemical Compounds
Nanoparticles Chemical Compounds
Chirality Chemical Compounds
Dendrimers Chemical Compounds
Polymerization Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1972 2020

1 Downloads (Pure)

Architecture-dependent interplay between self-assembly and crystallization in discrete block co-oligomers

Petkau-Milroy, K., Ianiro, A., Ahn, M. M. L., Magana, J. R., Vleugels, M. E. J., Lamers, B. A. G., Tuinier, R., Voets, I. K., Palmans, A. R. A. & Meijer, E. W., 2020, In : ACS Macro Letters. 9, p. 38-42 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Self assembly
Lactic acid
1 Downloads (Pure)

Distinct pathways in "thermally bisignate supramolecular polymerization": spectroscopic and computational studies

Rao, K. V., Mabesoone, M. F. J., Miyajima, D., Nihonyanagi, A., Meijer, E. W. & Aida, T., 8 Jan 2020, In : Journal of the American Chemical Society. 142, 1, p. 598-605 8 p.

Research output: Contribution to journalArticleAcademicpeer-review


Ditopic binuclear copper(II) complexes for DNA cleavage

Carreira-Barral, I., Riopedre-Fernández, M., de Blas, A., Mosquera, J., Vázquez, M. E., Platas-Iglesias, C. & Esteban-Gómez, D., Apr 2020, In : Journal of Inorganic Biochemistry. 205, 110995.

Research output: Contribution to journalArticleAcademicpeer-review

DNA Cleavage
Methyl Green


NWO Veni Award : Self-oscillating surfaces

G.M.E. Vantomme (Recipient), 2017

Prize: NWOVeniScientific


NWO Vidi Award : Adaptive materials with molecular light switches

I.K. Voets (Recipient), 2014

Prize: NWOVidiScientific


Activities 1992 2010

  • 10 Editorial activity
  • 2 Membership of board
  • 2 Membership of committee
  • 1 Contributed talk

Journal of the American Chemical Society (Journal)

E.W. (Bert) Meijer (Editorial board member)

Activity: Publication peer-review and editorial work typesEditorial activityScientific

Chemical Science (Journal)

E.W. (Bert) Meijer (Editorial board member)

Activity: Publication peer-review and editorial work typesEditorial activityScientific

DSM (External organisation)

E.W. (Bert) Meijer (Member)

Activity: Membership typesMembership of boardScientific

Press / Media

Light-controlled molecules: Scientists develop new recycling strategy

Fabian Eisenreich


2 items of Media coverage

Press/Media: Expert Comment

Discovery Could Enable Recycling of Non-Recyclable Plastics

Fabian Eisenreich


1 item of Media coverage

Press/Media: Expert Comment

Student theses

1,4,7-triazacyclononane functionalized BTA: a supramolecular polymer for cooperative catalysis

Author: Robeerst, C., 26 Jun 2019

Supervisor: Mabesoone, M. (Supervisor 1), Su, L. (Supervisor 2), Meijer, B. (Supervisor 2), Palmans, A. (Supervisor 2) & Schenning, A. (Supervisor 2)

Student thesis: Master

Bioactivation of electrospun UPy-based supramolecular polymer meshes: towards an improved treatment of pelvic floor dysfunctions

Author: Arts, B., 18 Dec 2017

Supervisor: Dankers, P. (Supervisor 1), Zaccaria, S. (Supervisor 2) & Meijer, B. (Supervisor 2)

Student thesis: Master

Block copolymers and crystallinity: pushing phase-separation to its limits

Author: Lamers, B., 22 Feb 2017

Supervisor: van Genabeek, B. (Supervisor 1), Palmans, A. (Supervisor 2) & Meijer, E. (Supervisor 2)

Student thesis: Master