• Het Kranenveld, Helix (STO 4.33)

    Eindhoven

    Netherlands

  • P.O. Box 513, Helix (STO 4.33)

    5600 MB Eindhoven

    Netherlands

Organization profile

Introduction / mission

How far can we push chemical self-assembly? Bridging the gap between life sciences and materials science, using organic chemistry and polymer chemistry. 

Highlighted phrase

Exploration of supramolecular systems and materials

Organisational profile

At the Macro Organic Chemistry group we educate young students to become independent scientists and make them experienced researchers in the design, synthesis, characterization and possible applications of complex molecular systems with unconventional properties. Our research addresses the challenging question “How far can we push chemical self-assembly?”. This ranges from detailed mechanistic (kinetic) investigations on the self-assembly processes of various molecular structures (e.g. the formation of ordered arrays, under thermodynamic control as well as through kinetic experiments) to the design, non-covalent synthesis and use of artificial mimics of enzymes and extracellular matrices. Our group is part of the overarching research group for Molecular Science and Technology.

From the start in 1991, our research has been focused on the design, synthesis, characterization and possible applications of new functional molecular architectures. Over the years we have worked on dendrimers, semi-conducting oligomers/polymers and several supramolecular units, with chirality as a muse. In the course of time, our focus has shifted towards the synthesis and study of complex molecular systems and in 2007 our group became the founding father of the Institute of Complex Molecular Systems (ICMS) at TU/e. More recently, a renewed interest in functional supramolecular materials for electronics and biomedical engineering has underpinned the relevance of our knowledge in the design and synthesis of molecular units that self-assemble in a controlled way, producing materials ordered at the mesoscale. 

In our current research we aim at closing the gap between organic chemistry, polymer chemistry and chemical biology by applying well-controlled supramolecular chemistry protocols. Central to this is our concept of multi-step non-covalent synthesis of molecular systems, using well-defined small and large molecules. We thus synthesize and study novel artificial molecular systems where the position of all molecules in the system can be controlled with respect to time and space. To arrive at dynamic functionalties of these molecular systems, we investigate the response to external stimuli both experimentally and theoretically.

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    Research Output

    Architecture-dependent interplay between self-assembly and crystallization in discrete block co-oligomers

    Petkau-Milroy, K., Ianiro, A., Ahn, M. M. L., Magana, J. R., Vleugels, M. E. J., Lamers, B. A. G., Tuinier, R., Voets, I. K., Palmans, A. R. A. & Meijer, E. W., 21 Jan 2020, In : ACS Macro Letters. 9, 1, p. 38-42 5 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    File
  • 11 Downloads (Pure)

    Distinct pathways in "thermally bisignate supramolecular polymerization": spectroscopic and computational studies

    Rao, K. V., Mabesoone, M. F. J., Miyajima, D., Nihonyanagi, A., Meijer, E. W. & Aida, T., 8 Jan 2020, In : Journal of the American Chemical Society. 142, 1, p. 598-605 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • 1 Citation (Scopus)
    1 Downloads (Pure)

    Ditopic binuclear copper(II) complexes for DNA cleavage

    Carreira-Barral, I., Riopedre-Fernández, M., de Blas, A., Mosquera, J., Vázquez, M. E., Platas-Iglesias, C. & Esteban-Gómez, D., Apr 2020, In : Journal of Inorganic Biochemistry. 205, April 2020, 13 p., 110995.

    Research output: Contribution to journalArticleAcademicpeer-review

  • 1 Downloads (Pure)

    Prizes

    Doctorem Honoris Causa of the Free Universitat Berlin

    E.W. (Bert) Meijer (Recipient), 2019

    Prize: OtherHonorary degreesScientific

    NWO Veni Award : Self-oscillating surfaces

    G.M.E. Vantomme (Recipient), 2017

    Prize: NWOVeniScientific

  • NWO Vidi Award : Adaptive materials with molecular light switches

    I.K. Voets (Recipient), 2014

    Prize: NWOVidiScientific

  • Activities

    • 10 Editorial activity
    • 3 Membership of committee
    • 2 Membership of board
    • 1 Contributed talk

    Max Planck Institute for Polymer Research (External organisation)

    E.W. (Bert) Meijer (Member)
    2018 → …

    Activity: Membership typesMembership of committeeScientific

    Chemical Science (Journal)

    E.W. (Bert) Meijer (Editorial board member)
    20102015

    Activity: Publication peer-review and editorial work typesEditorial activityScientific

    Journal of the American Chemical Society (Journal)

    E.W. (Bert) Meijer (Editorial board member)
    20102016

    Activity: Publication peer-review and editorial work typesEditorial activityScientific

    Student theses

    1,4,7-triazacyclononane functionalized BTA: a supramolecular polymer for cooperative catalysis

    Author: Robeerst, C., 26 Jun 2019

    Supervisor: Mabesoone, M. (Supervisor 1), Su, L. (Supervisor 2), Meijer, B. (Supervisor 2), Palmans, A. (Supervisor 2) & Schenning, A. (Supervisor 2)

    Student thesis: Master

    Bioactivation of electrospun UPy-based supramolecular polymer meshes: towards an improved treatment of pelvic floor dysfunctions

    Author: Arts, B., 18 Dec 2017

    Supervisor: Dankers, P. (Supervisor 1), Zaccaria, S. (Supervisor 2) & Meijer, B. (Supervisor 2)

    Student thesis: Master

    Block copolymers and crystallinity: pushing phase-separation to its limits

    Author: Lamers, B., 22 Feb 2017

    Supervisor: van Genabeek, B. (Supervisor 1), Palmans, A. (Supervisor 2) & Meijer, E. (Supervisor 2)

    Student thesis: Master

    File