Wavefront sensorless adaptive optics OCT with the DONE algorithm for in vivo human retinal imaging [invited]

Hans R.G.W. Verstraete, Morgan Heisler, Myeong Jin Ju, Daniel Wahl, Laurens Bliek, Jeroen Kalkman, Stefano Bonora, Yifan Jian, Michel Verhaegen, Marinko V. Sarunic

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

22 Citaten (Scopus)

Samenvatting

In this report, which is an international collaboration of OCT, adaptive optics, and control research, we demonstrate the data-based online nonlinear extremum-seeker (DONE) algorithm to guide the image based optimization for wavefront sensorless adaptive optics (WFSL-AO) OCT for in vivo human retinal imaging. The ocular aberrations were corrected using a multi-actuator adaptive lens after linearization of the hysteresis in the piezoelectric actuators. The DONE algorithm succeeded in drastically improving image quality and the OCT signal intensity, up to a factor seven, while achieving a computational time of 1 ms per iteration, making it applicable for many high speed applications. We demonstrate the correction of five aberrations using 70 iterations of the DONE algorithm performed over 2.8 s of continuous volumetric OCT acquisition. Data acquired from an imaging phantom and in vivo from human research volunteers are presented.

Originele taal-2Engels
Artikelnummer#280260
Pagina's (van-tot)2261-2275
Aantal pagina's15
TijdschriftBiomedical Optics Express
Volume8
Nummer van het tijdschrift4
DOI's
StatusGepubliceerd - 1 apr 2017
Extern gepubliceerdJa

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