Visible-light-promoted iron-catalyzed C(sp2)–C(sp3) Kumada cross-coupling in flow

Xiao Jing Wei, Irini Abdiaj, Carlo Sambiagio, Chenfei Li, Eli Zysman-Colman, Jesús Alcázar, Timothy Noël (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

18 Citaten (Scopus)
83 Downloads (Pure)


A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada–Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes’ residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application.

Originele taal-2Engels
Pagina's (van-tot)13030-13034
Aantal pagina's5
TijdschriftAngewandte Chemie - International Edition
Nummer van het tijdschrift37
StatusGepubliceerd - 9 sep 2019

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