Versatile microfluidic flow generated by moulded magnetic artificial cilia

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Magnetic artificial cilia (MAC) are flexible hair-like micro-actuators inspired by biological cilia. When integrated in a microfluidic device and actuated by an external (electro-)magnet, MAC can generate fluid flows. Our MAC are made of a composite material of polydimethylsiloxane (PDMS) and magnetic microparticles (Carbonyl iron powder). In this paper, we demonstrate a fabrication process based on micro-moulding to manufacture MAC, in which we can vary the magnetic particle distribution within the cilia from (1) a random distribution, to (2) a linearly aligned distribution to (3) a concentrated distribution in the tips of the cilia. Magnetization measurements show that the aligned distribution leads to a substantial increase of magnetic susceptibility, which dramatically enhances their response to an applied magnetic field. When integrated in a microfluidic channel, the improved MAC can induce versatile flows, for example (i) circulatory fluid flows with flow speeds up to 250 μm/s which is substantially above the performance of most of the previously developed artificial cilia, (ii) direction-reversible flows, (iii) oscillating flows, and (iv) pulsatile flows, by changing the magnetic actuation mode. Compared to other pumping methods, this on-chip/in-situ micro-pump requires no tubing or electric connections, reducing the usage of reagents by minimizing “dead volumes” avoiding undesirable electrical effects, and accommodating a wide range of different fluids. These results demonstrate that our MAC can be used as versatile integrated micropump in microfluidic devices, with great potential for future lab-on-a-chip applications.

Originele taal-2Engels
Pagina's (van-tot)614-624
Aantal pagina's11
TijdschriftSensors and Actuators, B: Chemical
Volume263
DOI's
StatusGepubliceerd - 15 jun 2018

Vingerafdruk

Microfluidics
Flow of fluids
microfluidic devices
Oscillating flow
fluid flow
Pulsatile flow
Lab-on-a-chip
Iron powder
chips
Polydimethylsiloxane
oscillating flow
Tubing
Magnetic susceptibility
Molding
Magnets
Magnetization
hair
microparticles
Actuators
statistical distributions

Citeer dit

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abstract = "Magnetic artificial cilia (MAC) are flexible hair-like micro-actuators inspired by biological cilia. When integrated in a microfluidic device and actuated by an external (electro-)magnet, MAC can generate fluid flows. Our MAC are made of a composite material of polydimethylsiloxane (PDMS) and magnetic microparticles (Carbonyl iron powder). In this paper, we demonstrate a fabrication process based on micro-moulding to manufacture MAC, in which we can vary the magnetic particle distribution within the cilia from (1) a random distribution, to (2) a linearly aligned distribution to (3) a concentrated distribution in the tips of the cilia. Magnetization measurements show that the aligned distribution leads to a substantial increase of magnetic susceptibility, which dramatically enhances their response to an applied magnetic field. When integrated in a microfluidic channel, the improved MAC can induce versatile flows, for example (i) circulatory fluid flows with flow speeds up to 250 μm/s which is substantially above the performance of most of the previously developed artificial cilia, (ii) direction-reversible flows, (iii) oscillating flows, and (iv) pulsatile flows, by changing the magnetic actuation mode. Compared to other pumping methods, this on-chip/in-situ micro-pump requires no tubing or electric connections, reducing the usage of reagents by minimizing “dead volumes” avoiding undesirable electrical effects, and accommodating a wide range of different fluids. These results demonstrate that our MAC can be used as versatile integrated micropump in microfluidic devices, with great potential for future lab-on-a-chip applications.",
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Versatile microfluidic flow generated by moulded magnetic artificial cilia. / Zhang, Shuaizhong; Wang, Ye; Lavrijsen, Reinoud; Onck, Patrick R.; den Toonder, J.M.J.

In: Sensors and Actuators, B: Chemical, Vol. 263, 15.06.2018, blz. 614-624.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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AU - Zhang, Shuaizhong

AU - Wang, Ye

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