Uittreksel
Magnetic artificial cilia (MAC) are flexible hair-like micro-actuators inspired by biological cilia. When integrated in a microfluidic device and actuated by an external (electro-)magnet, MAC can generate fluid flows. Our MAC are made of a composite material of polydimethylsiloxane (PDMS) and magnetic microparticles (Carbonyl iron powder). In this paper, we demonstrate a fabrication process based on micro-moulding to manufacture MAC, in which we can vary the magnetic particle distribution within the cilia from (1) a random distribution, to (2) a linearly aligned distribution to (3) a concentrated distribution in the tips of the cilia. Magnetization measurements show that the aligned distribution leads to a substantial increase of magnetic susceptibility, which dramatically enhances their response to an applied magnetic field. When integrated in a microfluidic channel, the improved MAC can induce versatile flows, for example (i) circulatory fluid flows with flow speeds up to 250 μm/s which is substantially above the performance of most of the previously developed artificial cilia, (ii) direction-reversible flows, (iii) oscillating flows, and (iv) pulsatile flows, by changing the magnetic actuation mode. Compared to other pumping methods, this on-chip/in-situ micro-pump requires no tubing or electric connections, reducing the usage of reagents by minimizing “dead volumes” avoiding undesirable electrical effects, and accommodating a wide range of different fluids. These results demonstrate that our MAC can be used as versatile integrated micropump in microfluidic devices, with great potential for future lab-on-a-chip applications.
| Originele taal-2 | Engels |
|---|---|
| Pagina's (van-tot) | 614-624 |
| Aantal pagina's | 11 |
| Tijdschrift | Sensors and Actuators, B: Chemical |
| Volume | 263 |
| DOI's | |
| Status | Gepubliceerd - 15 jun 2018 |
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Versatile microfluidic flow generated by moulded magnetic artificial cilia. / Zhang, Shuaizhong; Wang, Ye; Lavrijsen, Reinoud; Onck, Patrick R.; den Toonder, J.M.J.
In: Sensors and Actuators, B: Chemical, Vol. 263, 15.06.2018, blz. 614-624.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
TY - JOUR
T1 - Versatile microfluidic flow generated by moulded magnetic artificial cilia
AU - Zhang, Shuaizhong
AU - Wang, Ye
AU - Lavrijsen, Reinoud
AU - Onck, Patrick R.
AU - den Toonder, J.M.J.
PY - 2018/6/15
Y1 - 2018/6/15
N2 - Magnetic artificial cilia (MAC) are flexible hair-like micro-actuators inspired by biological cilia. When integrated in a microfluidic device and actuated by an external (electro-)magnet, MAC can generate fluid flows. Our MAC are made of a composite material of polydimethylsiloxane (PDMS) and magnetic microparticles (Carbonyl iron powder). In this paper, we demonstrate a fabrication process based on micro-moulding to manufacture MAC, in which we can vary the magnetic particle distribution within the cilia from (1) a random distribution, to (2) a linearly aligned distribution to (3) a concentrated distribution in the tips of the cilia. Magnetization measurements show that the aligned distribution leads to a substantial increase of magnetic susceptibility, which dramatically enhances their response to an applied magnetic field. When integrated in a microfluidic channel, the improved MAC can induce versatile flows, for example (i) circulatory fluid flows with flow speeds up to 250 μm/s which is substantially above the performance of most of the previously developed artificial cilia, (ii) direction-reversible flows, (iii) oscillating flows, and (iv) pulsatile flows, by changing the magnetic actuation mode. Compared to other pumping methods, this on-chip/in-situ micro-pump requires no tubing or electric connections, reducing the usage of reagents by minimizing “dead volumes” avoiding undesirable electrical effects, and accommodating a wide range of different fluids. These results demonstrate that our MAC can be used as versatile integrated micropump in microfluidic devices, with great potential for future lab-on-a-chip applications.
AB - Magnetic artificial cilia (MAC) are flexible hair-like micro-actuators inspired by biological cilia. When integrated in a microfluidic device and actuated by an external (electro-)magnet, MAC can generate fluid flows. Our MAC are made of a composite material of polydimethylsiloxane (PDMS) and magnetic microparticles (Carbonyl iron powder). In this paper, we demonstrate a fabrication process based on micro-moulding to manufacture MAC, in which we can vary the magnetic particle distribution within the cilia from (1) a random distribution, to (2) a linearly aligned distribution to (3) a concentrated distribution in the tips of the cilia. Magnetization measurements show that the aligned distribution leads to a substantial increase of magnetic susceptibility, which dramatically enhances their response to an applied magnetic field. When integrated in a microfluidic channel, the improved MAC can induce versatile flows, for example (i) circulatory fluid flows with flow speeds up to 250 μm/s which is substantially above the performance of most of the previously developed artificial cilia, (ii) direction-reversible flows, (iii) oscillating flows, and (iv) pulsatile flows, by changing the magnetic actuation mode. Compared to other pumping methods, this on-chip/in-situ micro-pump requires no tubing or electric connections, reducing the usage of reagents by minimizing “dead volumes” avoiding undesirable electrical effects, and accommodating a wide range of different fluids. These results demonstrate that our MAC can be used as versatile integrated micropump in microfluidic devices, with great potential for future lab-on-a-chip applications.
KW - Lab-on-Chip
KW - Magnetic artificial cilia
KW - Magnetic particle distribution
KW - Micro-moulding
KW - Micro-pump
KW - Versatile microfluidic flow
UR - http://www.scopus.com/inward/record.url?scp=85042716812&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2018.01.189
DO - 10.1016/j.snb.2018.01.189
M3 - Article
AN - SCOPUS:85042716812
VL - 263
SP - 614
EP - 624
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
SN - 0925-4005
ER -