Using dendrimers for the engineering of synthetic vaccines

J.G. Linhardt; D.W.P.M. Lowik; E.W. Meijer; J.C.M. van Hest

Using dendrimers for the engineering of synthetic vaccines

J.G. Linhardt
, D.W.P.M. Lowik
, E.W. Meijer
, J.C.M. van Hest

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic

Samenvatting

To study the ability of dendrimer-supported peptides to act as vaccines, four peptides based on the structure of malaria parasite Plasmodium falciparum CS protein were synthesized, modified with a 'click-tail' which will enable insertion of the peptide into a dendrimer via 'clicking' into the interstices between dendrimer end groups. CD spectroscopy of the four peptides showed random coil behavior in aq. soln. in the absence of dendrimer. The four peptides were Ac-P8, (P8 = Gly-Ala-Asn-Pro-Asn-Ala-Ala-Gly-), Click-P8 (Click = -NH(CH2)6NHC(O)NHCH2CO2H), Ac-P8-Click, and Click-P8-Click

Originele taal-2	Engels
Pagina's (van-tot)	799-
Aantal pagina's	1
Tijdschrift	Polymer Preprints
Volume	43
Nummer van het tijdschrift	2
Status	Gepubliceerd - 2002
Evenement	228th ACS National Meeting - Philadelphia, Verenigde Staten van Amerika Duur: 22 aug. 2004 → 26 aug. 2004

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title = "Using dendrimers for the engineering of synthetic vaccines",

abstract = "To study the ability of dendrimer-supported peptides to act as vaccines, four peptides based on the structure of malaria parasite Plasmodium falciparum CS protein were synthesized, modified with a 'click-tail' which will enable insertion of the peptide into a dendrimer via 'clicking' into the interstices between dendrimer end groups. CD spectroscopy of the four peptides showed random coil behavior in aq. soln. in the absence of dendrimer. The four peptides were Ac-P8, (P8 = Gly-Ala-Asn-Pro-Asn-Ala-Ala-Gly-), Click-P8 (Click = -NH(CH2)6NHC(O)NHCH2CO2H), Ac-P8-Click, and Click-P8-Click",

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year = "2002",

language = "English",

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T1 - Using dendrimers for the engineering of synthetic vaccines

AU - Linhardt, J.G.

AU - Lowik, D.W.P.M.

AU - Meijer, E.W.

AU - van Hest, J.C.M.

PY - 2002

Y1 - 2002

N2 - To study the ability of dendrimer-supported peptides to act as vaccines, four peptides based on the structure of malaria parasite Plasmodium falciparum CS protein were synthesized, modified with a 'click-tail' which will enable insertion of the peptide into a dendrimer via 'clicking' into the interstices between dendrimer end groups. CD spectroscopy of the four peptides showed random coil behavior in aq. soln. in the absence of dendrimer. The four peptides were Ac-P8, (P8 = Gly-Ala-Asn-Pro-Asn-Ala-Ala-Gly-), Click-P8 (Click = -NH(CH2)6NHC(O)NHCH2CO2H), Ac-P8-Click, and Click-P8-Click

AB - To study the ability of dendrimer-supported peptides to act as vaccines, four peptides based on the structure of malaria parasite Plasmodium falciparum CS protein were synthesized, modified with a 'click-tail' which will enable insertion of the peptide into a dendrimer via 'clicking' into the interstices between dendrimer end groups. CD spectroscopy of the four peptides showed random coil behavior in aq. soln. in the absence of dendrimer. The four peptides were Ac-P8, (P8 = Gly-Ala-Asn-Pro-Asn-Ala-Ala-Gly-), Click-P8 (Click = -NH(CH2)6NHC(O)NHCH2CO2H), Ac-P8-Click, and Click-P8-Click

M3 - Article

SN - 0032-3934

VL - 43

SP - 799-

JO - Polymer Preprints

JF - Polymer Preprints

IS - 2

T2 - 228th ACS National Meeting

Y2 - 22 August 2004 through 26 August 2004

ER -

Using dendrimers for the engineering of synthetic vaccines

Samenvatting

Duurzame ontwikkelingsdoelstellingen van de VN

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