Traumatic Brain Injury at Multiple Length Scales: Relating Diffuse Axonal Injury to Discrete Axonal Impairment

R.J.H. Cloots, J.A.W. Dommelen, van, S. Kleiven, M.G.D. Geers

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

11 Citaten (Scopus)

Samenvatting

The length scales involved in the development of diffuse axonal injury, typically range from thehead level (i.e., mechanical loading) to the cellular level, where discrete axonal injuries are located nearinclusions. The aim is to investigate the local axonal strains near an inclusion in relation to the tissue level strains of the brain stem during mechanical loading of the head and the resulting orientation dependence of tissue level injury criteria. For this, a multi-scale FE approach is adopted. The results show that the axonal strains cannot be trivially correlated to the tissue strain without taking into account the axonal orientations, which indicates that the heterogeneities at the cellular level play an important role in brain injury and reliable predictions of it.
Originele taal-2Engels
TitelProceedings of the International Conference on the Biomechanics of Impact, IRCOBI
Plaats van productieGermany, Hannover
Pagina's119-130
StatusGepubliceerd - 2010

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Citeer dit

Cloots, R. J. H., Dommelen, van, J. A. W., Kleiven, S., & Geers, M. G. D. (2010). Traumatic Brain Injury at Multiple Length Scales: Relating Diffuse Axonal Injury to Discrete Axonal Impairment. In Proceedings of the International Conference on the Biomechanics of Impact, IRCOBI (blz. 119-130). Germany, Hannover.