Transient ordered domains in single-component phospholipid bilayers

T. Murtola, T. Róg, E. Falck, M.E.J. Karttunen, I. Vattulainen

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    We report evidence of dense, ordered nanodomains in single-component fluid lipid bilayers. Our atomic-scale molecular dynamics simulations suggest that the area available to a lipid acyl chain exhibits large fluctuations, resulting in denser and sparser domains. The sizes of the dense domains can be up to ~10¿¿nm, and their lifetimes are of the order of ~10¿¿ns. In addition, our simulations suggest that domains of lipids with highly ordered acyl chains form predominantly within the dense regions, their sizes ranging from a few chains up to a few nanometers, and with lifetimes between ~10¿¿ps–10¿¿ns. These observations shed light on the origin of experimentally observed fluctuations, as well as on the mechanisms of phase transitions in lipid membranes.
    Originele taal-2Engels
    Pagina's (van-tot)238102-1/4
    TijdschriftPhysical Review Letters
    Nummer van het tijdschrift23
    StatusGepubliceerd - 2006

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