Transcatheter-delivered expandable bioresorbable polymeric graft with stenting capacity induces vascular regeneration

Renee Duijvelshoff; Maria S. Cabrera; Bart Sanders; Sylvia Dekker; Anthal I.P.M. Smits; Frank P.T. Baaijens; Carlijn V.C. Bouten

doi:10.1016/j.jacbts.2020.09.005

Transcatheter-delivered expandable bioresorbable polymeric graft with stenting capacity induces vascular regeneration

Renee Duijvelshoff, Maria S. Cabrera, Bart Sanders, Sylvia Dekker, Anthal I.P.M. Smits, Frank P.T. Baaijens, Carlijn V.C. Bouten (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

9 Citaten (Scopus)

Samenvatting

As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.

Originele taal-2	Engels
Pagina's (van-tot)	1095-1110
Aantal pagina's	16
Tijdschrift	JACC: Basic to Translational Science
Volume	5
Nummer van het tijdschrift	11
DOI's	https://doi.org/10.1016/j.jacbts.2020.09.005
Status	Gepubliceerd - nov. 2020

Financiering

The authors thank Dr. Serena Buscone and Arturo Lichauco, MSc, (Department of Biomedical Engineering, Eindhoven University of Technology) for assistance and expert advice on histology, and Prof. Dr. Patricia Dankers for critical analysis of the manuscript. This work was funded by a grant from the Dutch government to the Netherlands Institute for Regenerative Medicine (grant FES0908). The authors gratefully acknowledge funding from the Ministry of Education, Culture and Science for the Gravitation Program 024.003.103 “Materials Driven Regeneration.” Stentit provided funding to this study through a soft loan provided by the Dutch government (STW Take-Off Phase 2, project 15672). Drs. Bart Sanders and Maria Cabrera are founders and shareholders of Stentit B.V. Drs. Bart Sanders, Maria S. Cabrera, and Frank P.T. Baaijens are the holders of a patent related to the presented graft technology. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Financiers	Financiernummer
Dutch government
Netherlands Institute for Regenerative Medicine	FES0908
Technische Universiteit Eindhoven
Ministerio de Educación, Cultura y Deporte

Toegang tot document

10.1016/j.jacbts.2020.09.005Licentie: CC BY-NC-ND

Andere bestanden en links

Link naar publicatie in Scopus

Citeer dit

@article{5db330cbee654b49bc5c21146f845875,

title = "Transcatheter-delivered expandable bioresorbable polymeric graft with stenting capacity induces vascular regeneration",

abstract = "As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.",

keywords = "elastin, regeneration, tissue engineering, transcatheter delivery, vascular graft",

author = "Renee Duijvelshoff and Cabrera, {Maria S.} and Bart Sanders and Sylvia Dekker and Smits, {Anthal I.P.M.} and Baaijens, {Frank P.T.} and Bouten, {Carlijn V.C.}",

year = "2020",

month = nov,

doi = "10.1016/j.jacbts.2020.09.005",

language = "English",

volume = "5",

pages = "1095--1110",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

publisher = "Elsevier",

number = "11",

}

TY - JOUR

T1 - Transcatheter-delivered expandable bioresorbable polymeric graft with stenting capacity induces vascular regeneration

AU - Duijvelshoff, Renee

AU - Cabrera, Maria S.

AU - Sanders, Bart

AU - Dekker, Sylvia

AU - Smits, Anthal I.P.M.

AU - Baaijens, Frank P.T.

AU - Bouten, Carlijn V.C.

PY - 2020/11

Y1 - 2020/11

N2 - As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.

AB - As the next step in the translation of vascular tissue engineering, this study uniquely combines transcatheter delivery and in situ tissue regeneration using a novel bioresorbable electrospun polymer graft that can be implanted minimally invasively. Once delivered inside a small-diameter vessel, the electrospun microstructure supports the vessel wall, facilitates cellular infiltration, and guides organized tissue formation.

KW - elastin

KW - regeneration

KW - tissue engineering

KW - transcatheter delivery

KW - vascular graft

UR - http://www.scopus.com/inward/record.url?scp=85097386003&partnerID=8YFLogxK

U2 - 10.1016/j.jacbts.2020.09.005

DO - 10.1016/j.jacbts.2020.09.005

M3 - Article

C2 - 33294741

SN - 2452-302X

VL - 5

SP - 1095

EP - 1110

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 11

ER -

Transcatheter-delivered expandable bioresorbable polymeric graft with stenting capacity induces vascular regeneration

Samenvatting

Financiering

Toegang tot document

Andere bestanden en links

Vingerafdruk

Citeer dit