Tracking of environmental determinants of bone structure and strength development in healthy boys: an eight-year follow up study on the positive interaction between physical activity and protein intake from prepuberty to mid-late adolescence

T. Chevalley, J.P. Bonjour, B. Rietbergen, van, S. Ferrari, R. Rizzoli

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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Samenvatting

High protein (> median:Hprot) vs. moderate (<median:MProt) intake was shown to enhance the positive impact of high physical activity (HPA) on proximal femur BMC/aBMD/Area in healthy prepubertal boys. We tested the hypothesis that this synergistic effect would track and influence bone structure and strength until mid-adolescence. BMC/aBMD/Area was measured at femoral neck (FN) and total hip (TotHip) by DXA in 176 boys at 7.4¿±¿0.4 and 15.2¿±¿0.5 years (±¿SD). Distal tibia (DistTib) microstructure and strength were also assessed at 15.2 years by high-resolution peripheral computerized tomography (HR-pQCT) and micro-finite element analysis (µFEA). The positive impact of HProt vs. MProt on FN and TotHip BMC/aBMD/Area, recorded at 7.4 years remained unabated at 15.2 years. At this age, at DistTib, HProt-HPA vs. MProt-HPA was associated (p¿
Originele taal-2Engels
Pagina's (van-tot)2182-2192
TijdschriftJournal of Bone and Mineral Research
Volume29
Nummer van het tijdschrift10
DOI's
StatusGepubliceerd - 2014

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