Towards in vivo photoacoustic imaging of vulnerable plaques in the carotid artery

Jan-Willem Muller; Roy P.M. van Hees; Marc R.H.M. van Sambeek; Pierre Boutouyrie; Marcel C.M. Rutten; Peter Brands; Min Wu; Richard G.P. Lopata

doi:10.1364/BOE.430064

Towards in vivo photoacoustic imaging of vulnerable plaques in the carotid artery

Jan-Willem Muller (Corresponding author), Roy P.M. van Hees, Marc R.H.M. van Sambeek, Pierre Boutouyrie, Marcel C.M. Rutten, Peter Brands, Min Wu, Richard G.P. Lopata

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

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The main indicator for endarterectomy is the grade of stenosis, which results in severe overtreatment. Photoacoustic imaging (PAI) can provide patient-specific assessment of plaque morphology, and thereby vulnerability. A pilot study of PAI on carotid plaques in patients (n=16) was performed intraoperatively with a hand-held PAI system. By compensating for motion, the photoacoustic (PA) signal-to-noise ratio (SNR) could be increased by 5 dB in vivo. PA signals from hemorrhagic plaques had different characteristics compared to the signals from the carotid blood pool. This study is a key step towards a non-invasive application of PAI to detect vulnerable plaques.

Originele taal-2	Engels
Pagina's (van-tot)	4207-4218
Aantal pagina's	12
Tijdschrift	Biomedical Optics Express
Volume	12
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1364/BOE.430064
Status	Gepubliceerd - 1 jul. 2021

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AU - Rutten, Marcel C.M.

AU - Brands, Peter

AU - Wu, Min

AU - Lopata, Richard G.P.

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Towards in vivo photoacoustic imaging of vulnerable plaques in the carotid artery

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