The synthesis of phencyclidine and other 1-arylcyclohexylamines

V.H. Maddox, E.F. Godefroi, R.F. Parcell

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

181 Citaten (Scopus)
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Various 1-arylcyclohexylamines were synthesized for evaluation as central nervous system depressants. The compounds were prepared by several procedures. 1-(1-Phenylcyclohexyl)piperidine, the first compound of this type synthesized, was prepared from 1-piperidinocyclohexanecarbonitrile by replacement of the cyano group by phenyl using phenylmagnesium bromide. These compounds were tested for cataleptoid activity and antitonic extensor properties.
Originele taal-2Engels
Pagina's (van-tot)230-235
Aantal pagina's6
TijdschriftJournal of Medicinal Chemistry
Nummer van het tijdschrift2
StatusGepubliceerd - 1965


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