TY - JOUR
T1 - The SPECTRA Collaboration OMERACT Special Interest Group
T2 - Current research and future directions
AU - Stok, K.S.
AU - Finzel, S.
AU - Burghardt, A.J.
AU - Conaghan, P.G.
AU - Barnabe, C.
AU - Boyd, S.K.
AU - Martin, L.
AU - Barr, S.G.
AU - Feehan, L.
AU - Van Veenendaal, M.
AU - Cheung, A.
AU - Yeung, R.
AU - Schett, G.
AU - Tzaribachev, N.
AU - Engelke, K.
AU - Li, X.
AU - Pedoia, V.
AU - Jiang, Y.
AU - Troy, K.
AU - Baker, J.
AU - Van Den Bergh, J.
AU - Geusens, P.
AU - van Rietbergen, B.
AU - Willems, P.C.
AU - de Jong, J.
AU - Van Tubergen, A.
AU - Marotte, H.
AU - Chapurlat, R.
AU - Boutroy, S.
AU - Jullien, D.
AU - Lespessailles, E.
AU - Ibrahim, N.
AU - Stengaard-Pedersen, K.
AU - Keller, K.
AU - Hauge, E.M.
AU - Kocijan, R.
AU - Dejaco, C.
AU - Vilayphiou, N.
AU - Kraus, S.
AU - Pereira, R.
AU - Figueiredo, C.
AU - Messina, O.D.
AU - Qin, L.
AU - Tam, L.S.
AU - SPECTRA Collaboration
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Objective. High-resolution peripheral quantitative computed tomography (HR-pQCT) has the potential to improve radiographic progression determination in clinical trials and longitudinal observational studies. The goal of this work was to describe the current state of research presented at Outcome Measures in Rheumatology (OMERACT) 2016 and ensuing future directions outlined during discussion among attendees. Methods. At OMERACT 2016, SPECTRA (Study grouP for xtrEme-Computed Tomography in Rheumatoid Arthritis) introduced efforts to (1) validate the HR-pQCT according to OMERACT guidelines, focusing on rheumatoid arthritis (RA), and (2) find alternatives for automated joint space width (JSW) analysis. The Special Interest Group (SIG) was presented to patient research partners, physicians/ researchers, and SIG leaders followed by a 40-min discussion on future directions. Results. A consensus definition for RA erosion using HR-pQCT was demonstrated through a systematic literature review and a Delphi exercise. Histopathology and perfusion studies were presented that analyzed the true characteristics of cortical breaks in HR-pQCT images, and to provide criterion validity. Results indicate that readers were able to discriminate between erosion and small vascular channels. Moderate reliability (ICC 0.206-0.871) of direct erosion size measures was shown, which improved (> 0.9) only when experienced readers were considered. Quantification of erosion size was presented for scoring, direct measurement, and volumetric approaches, as well as a reliability exercise for direct measurement. Three methods for JSW measurement were compared, all indicating excellent reproducibility with differences at the extremes (i.e., near-zero and joint edge thickness). Conclusion. Initial reports on HR-pQCT are promising; however, to consider its use in clinical trials and longitudinal observational studies, it is imperative to assess the responsiveness of erosion measurement quantification.
AB - Objective. High-resolution peripheral quantitative computed tomography (HR-pQCT) has the potential to improve radiographic progression determination in clinical trials and longitudinal observational studies. The goal of this work was to describe the current state of research presented at Outcome Measures in Rheumatology (OMERACT) 2016 and ensuing future directions outlined during discussion among attendees. Methods. At OMERACT 2016, SPECTRA (Study grouP for xtrEme-Computed Tomography in Rheumatoid Arthritis) introduced efforts to (1) validate the HR-pQCT according to OMERACT guidelines, focusing on rheumatoid arthritis (RA), and (2) find alternatives for automated joint space width (JSW) analysis. The Special Interest Group (SIG) was presented to patient research partners, physicians/ researchers, and SIG leaders followed by a 40-min discussion on future directions. Results. A consensus definition for RA erosion using HR-pQCT was demonstrated through a systematic literature review and a Delphi exercise. Histopathology and perfusion studies were presented that analyzed the true characteristics of cortical breaks in HR-pQCT images, and to provide criterion validity. Results indicate that readers were able to discriminate between erosion and small vascular channels. Moderate reliability (ICC 0.206-0.871) of direct erosion size measures was shown, which improved (> 0.9) only when experienced readers were considered. Quantification of erosion size was presented for scoring, direct measurement, and volumetric approaches, as well as a reliability exercise for direct measurement. Three methods for JSW measurement were compared, all indicating excellent reproducibility with differences at the extremes (i.e., near-zero and joint edge thickness). Conclusion. Initial reports on HR-pQCT are promising; however, to consider its use in clinical trials and longitudinal observational studies, it is imperative to assess the responsiveness of erosion measurement quantification.
KW - 3-D imaging
KW - Metacarpophalangeal joint
KW - Omeract
KW - Radiographic computed tomography
KW - Rheumatoid arthritis
KW - Severity of Illness Index
KW - Reproducibility of Results
KW - Rheumatology/trends
KW - Rheumatic Diseases/diagnostic imaging
KW - Humans
KW - Tomography, X-Ray Computed
KW - Disease Progression
KW - Metacarpophalangeal Joint/diagnostic imaging
UR - http://www.scopus.com/inward/record.url?scp=85037165566&partnerID=8YFLogxK
U2 - 10.3899/jrheum.161197
DO - 10.3899/jrheum.161197
M3 - Article
C2 - 28765253
AN - SCOPUS:85037165566
SN - 0315-162X
VL - 44
SP - 1911
EP - 1915
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 12
ER -