Samenvatting
Many patients with end-stage heart disease die because of the scarcity of donor hearts. A total artificial heart (TAH), an implantable machine that replaces the heart, has so far been successfully used in over 1,700 patients as a temporary life-saving technology for bridging to heart transplantation. However, after more than six decades of research on TAHs, a TAH that is suitable for destination therapy is not yet available. High complication rates, bulky devices, poor durability, poor biocompatibility and low patient quality of life are some of the major drawbacks of current TAH devices that must be addressed before TAHs can be used as a destination therapy. Quickly emerging innovations in battery technology, wireless energy transmission, biocompatible materials and soft robotics are providing a promising opportunity for TAH development and might help to solve the drawbacks of current TAHs. In this Review, we describe the milestones in the history of TAH research and reflect on lessons learned during TAH development. We summarize the differences in the working mechanisms of these devices, discuss the next generation of TAHs and highlight emerging technologies that will promote TAH development in the coming decade. Finally, we present current challenges and future perspectives for the field.
| Originele taal-2 | Engels |
|---|---|
| Pagina's (van-tot) | 813-828 |
| Aantal pagina's | 16 |
| Tijdschrift | Nature Reviews. Cardiology |
| Volume | 19 |
| Nummer van het tijdschrift | 12 |
| DOI's | |
| Status | Gepubliceerd - dec. 2022 |
Bibliografische nota
Publisher Copyright:© 2022, Springer Nature Limited.
Financiering
The authors are grateful to L. C. van Laake (AMOLF, Netherlands), D. Zrinscak (Scuola Superiore Sant’Anna, Italy) and A. Henseler (evos GmbH, Germany) for their contributions and discussions; D. van Urk (Amsterdam UMC, The Netherlands) for assisting with screening and selecting articles; T. Azami (Amsterdam UMC, The Netherlands) and C. M. van de Beek (Amsterdam UMC, The Netherlands) for assistance with data extraction; C. E. J. M. Limpens (Amsterdam UMC, The Netherlands) and A. Malekzadeh (Amsterdam UMC, The Netherlands) for their help with the literature search; and ReinHeart TAH GmbH, Germany for providing additional data upon request. The authors’ work is part of the HybridHeart project and is funded by the European Union Horizon 2020 research and innovation programme under grant agreement no. 767195. The authors are grateful to L. C. van Laake (AMOLF, Netherlands), D. Zrinscak (Scuola Superiore Sant’Anna, Italy) and A. Henseler (evos GmbH, Germany) for their contributions and discussions; D. van Urk (Amsterdam UMC, The Netherlands) for assisting with screening and selecting articles; T. Azami (Amsterdam UMC, The Netherlands) and C. M. van de Beek (Amsterdam UMC, The Netherlands) for assistance with data extraction; C. E. J. M. Limpens (Amsterdam UMC, The Netherlands) and A. Malekzadeh (Amsterdam UMC, The Netherlands) for their help with the literature search; and ReinHeart TAH GmbH, Germany for providing additional data upon request. The authors’ work is part of the HybridHeart project and is funded by the European Union Horizon 2020 research and innovation programme under grant agreement no. 767195.