The influence of betamethasone on fetal heart rate variability, obtained by non-invasive fetal electrocardiogram recordings

Kim M.J. Verdurmen, Guy J.J. Warmerdam, Carlijn Lempersz, Alexandra D.J. Hulsenboom, Joris Renckens, Jeanne P. Dieleman, Rik Vullings, Judith O.E.H. van Laar, S. Guid Oei

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

  • 1 Citaties

Uittreksel

Background: Betamethasone is widely used to enhance fetal lung maturation in case of threatened preterm labour. Fetal heart rate variability is one of the most important parameters to assess in fetal monitoring, since it is a reliable indicator for fetal distress. Aim: To describe the effect of betamethasone on fetal heart rate variability, by applying spectral analysis on non-invasive fetal electrocardiogram recordings. Study design: Prospective cohort study. Subjects: Patients that require betamethasone, with a gestational age from 24 weeks onwards. Outcome measures: Fetal heart rate variability parameters on day 1, 2, and 3 after betamethasone administration are compared to a reference measurement. Results: Following 68 inclusions, 12 patients remained with complete series of measurements and sufficient data quality. During day 1, an increase in absolute fetal heart rate variability values was seen. During day 2, a decrease in these values was seen. All trends indicate to return to pre-medication values on day 3. Normalised high- and low-frequency power show little changes during the study period. Conclusions: The changes in fetal heart rate variability following betamethasone administration show the same pattern when calculated by spectral analysis of the fetal electrocardiogram, as when calculated by cardiotocography. Since normalised spectral values show little changes, the influence of autonomic modulation seems minor.

TaalEngels
Pagina's8-14
Aantal pagina's7
TijdschriftEarly Human Development
Volume119
DOI's
StatusGepubliceerd - 1 apr 2018

Vingerafdruk

Betamethasone
Fetal Heart Rate
Electrocardiography
Cardiotocography
Fetal Monitoring
Fetal Distress
Premature Obstetric Labor
Gestational Age
Cohort Studies
Outcome Assessment (Health Care)
Prospective Studies
Lung

Trefwoorden

    Citeer dit

    @article{a5f5303a289d487a832937bff2e10569,
    title = "The influence of betamethasone on fetal heart rate variability, obtained by non-invasive fetal electrocardiogram recordings",
    abstract = "Background: Betamethasone is widely used to enhance fetal lung maturation in case of threatened preterm labour. Fetal heart rate variability is one of the most important parameters to assess in fetal monitoring, since it is a reliable indicator for fetal distress. Aim: To describe the effect of betamethasone on fetal heart rate variability, by applying spectral analysis on non-invasive fetal electrocardiogram recordings. Study design: Prospective cohort study. Subjects: Patients that require betamethasone, with a gestational age from 24 weeks onwards. Outcome measures: Fetal heart rate variability parameters on day 1, 2, and 3 after betamethasone administration are compared to a reference measurement. Results: Following 68 inclusions, 12 patients remained with complete series of measurements and sufficient data quality. During day 1, an increase in absolute fetal heart rate variability values was seen. During day 2, a decrease in these values was seen. All trends indicate to return to pre-medication values on day 3. Normalised high- and low-frequency power show little changes during the study period. Conclusions: The changes in fetal heart rate variability following betamethasone administration show the same pattern when calculated by spectral analysis of the fetal electrocardiogram, as when calculated by cardiotocography. Since normalised spectral values show little changes, the influence of autonomic modulation seems minor.",
    keywords = "Betamethasone, Corticosteroid, Fetal electrocardiogram, Fetal heart rate variability",
    author = "Verdurmen, {Kim M.J.} and Warmerdam, {Guy J.J.} and Carlijn Lempersz and Hulsenboom, {Alexandra D.J.} and Joris Renckens and Dieleman, {Jeanne P.} and Rik Vullings and {van Laar}, {Judith O.E.H.} and Oei, {S. Guid}",
    year = "2018",
    month = "4",
    day = "1",
    doi = "10.1016/j.earlhumdev.2018.02.011",
    language = "English",
    volume = "119",
    pages = "8--14",
    journal = "Early Human Development",
    issn = "0378-3782",
    publisher = "Elsevier Ireland Ltd",

    }

    The influence of betamethasone on fetal heart rate variability, obtained by non-invasive fetal electrocardiogram recordings. / Verdurmen, Kim M.J.; Warmerdam, Guy J.J.; Lempersz, Carlijn; Hulsenboom, Alexandra D.J.; Renckens, Joris; Dieleman, Jeanne P.; Vullings, Rik; van Laar, Judith O.E.H.; Oei, S. Guid.

    In: Early Human Development, Vol. 119, 01.04.2018, blz. 8-14.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    TY - JOUR

    T1 - The influence of betamethasone on fetal heart rate variability, obtained by non-invasive fetal electrocardiogram recordings

    AU - Verdurmen,Kim M.J.

    AU - Warmerdam,Guy J.J.

    AU - Lempersz,Carlijn

    AU - Hulsenboom,Alexandra D.J.

    AU - Renckens,Joris

    AU - Dieleman,Jeanne P.

    AU - Vullings,Rik

    AU - van Laar,Judith O.E.H.

    AU - Oei,S. Guid

    PY - 2018/4/1

    Y1 - 2018/4/1

    N2 - Background: Betamethasone is widely used to enhance fetal lung maturation in case of threatened preterm labour. Fetal heart rate variability is one of the most important parameters to assess in fetal monitoring, since it is a reliable indicator for fetal distress. Aim: To describe the effect of betamethasone on fetal heart rate variability, by applying spectral analysis on non-invasive fetal electrocardiogram recordings. Study design: Prospective cohort study. Subjects: Patients that require betamethasone, with a gestational age from 24 weeks onwards. Outcome measures: Fetal heart rate variability parameters on day 1, 2, and 3 after betamethasone administration are compared to a reference measurement. Results: Following 68 inclusions, 12 patients remained with complete series of measurements and sufficient data quality. During day 1, an increase in absolute fetal heart rate variability values was seen. During day 2, a decrease in these values was seen. All trends indicate to return to pre-medication values on day 3. Normalised high- and low-frequency power show little changes during the study period. Conclusions: The changes in fetal heart rate variability following betamethasone administration show the same pattern when calculated by spectral analysis of the fetal electrocardiogram, as when calculated by cardiotocography. Since normalised spectral values show little changes, the influence of autonomic modulation seems minor.

    AB - Background: Betamethasone is widely used to enhance fetal lung maturation in case of threatened preterm labour. Fetal heart rate variability is one of the most important parameters to assess in fetal monitoring, since it is a reliable indicator for fetal distress. Aim: To describe the effect of betamethasone on fetal heart rate variability, by applying spectral analysis on non-invasive fetal electrocardiogram recordings. Study design: Prospective cohort study. Subjects: Patients that require betamethasone, with a gestational age from 24 weeks onwards. Outcome measures: Fetal heart rate variability parameters on day 1, 2, and 3 after betamethasone administration are compared to a reference measurement. Results: Following 68 inclusions, 12 patients remained with complete series of measurements and sufficient data quality. During day 1, an increase in absolute fetal heart rate variability values was seen. During day 2, a decrease in these values was seen. All trends indicate to return to pre-medication values on day 3. Normalised high- and low-frequency power show little changes during the study period. Conclusions: The changes in fetal heart rate variability following betamethasone administration show the same pattern when calculated by spectral analysis of the fetal electrocardiogram, as when calculated by cardiotocography. Since normalised spectral values show little changes, the influence of autonomic modulation seems minor.

    KW - Betamethasone

    KW - Corticosteroid

    KW - Fetal electrocardiogram

    KW - Fetal heart rate variability

    UR - http://www.scopus.com/inward/record.url?scp=85042703131&partnerID=8YFLogxK

    U2 - 10.1016/j.earlhumdev.2018.02.011

    DO - 10.1016/j.earlhumdev.2018.02.011

    M3 - Article

    VL - 119

    SP - 8

    EP - 14

    JO - Early Human Development

    T2 - Early Human Development

    JF - Early Human Development

    SN - 0378-3782

    ER -