The Impact of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) versus Conventional Surgery on Patient-Reported Outcomes: A Comparative Cohort Study between the CAIRO6 Trial and the PROCORE Study

Checca Bakkers; Vincent C.J. van de Vlasakker; Koen P.B. Rovers; Robin J. Lurvink; Simon W. Nienhuijs; Jacobus W.A. Burger; Geert Jan M. Creemers; Cynthia S. Bonhof; Floortje Mols; Ignace H.J.T. de Hingh

doi:10.3390/cancers15030788

The Impact of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) versus Conventional Surgery on Patient-Reported Outcomes: A Comparative Cohort Study between the CAIRO6 Trial and the PROCORE Study

Checca Bakkers
, Vincent C.J. van de Vlasakker
, Koen P.B. Rovers
, Robin J. Lurvink
, Simon W. Nienhuijs
, Jacobus W.A. Burger
, Geert Jan M. Creemers
, Cynthia S. Bonhof
, Floortje Mols
, Ignace H.J.T. de Hingh

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

6 Citaten (Scopus)

Samenvatting

Purpose—To compare patient-reported outcomes (PROs) of patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for colorectal peritoneal metastases to PROs of colorectal cancer (CRC) patients undergoing conventional surgery. Methods—Data were extracted from the CAIRO6 trial (CRS-HIPEC group) and the PROCORE study (conventional surgery group). Nine predefined PROs (derived from the EORTC QLQ-C30 questionnaire) were compared at baseline, in the early postoperative period and one year postoperatively, with correction for treatment with systemic therapy using linear mixed modeling. Results—In total, 331 patients were included: 71 in the CRS-HIPEC group and 260 in the conventional surgery group. All predefined PROs (fatigue, diarrhea, C30 summary score, Global Health Status, physical, role, emotional, cognitive, and social functioning) did not differ significantly between the groups at all three timepoints, and differential effects over time for all PROs did not differ significantly between the groups. Significant worsening of fatigue, C30 summary score, physical and role functioning (both groups), and cognitive and social functioning (conventional surgery group only) was present in the early postoperative period. All scores returned to baseline at one year postoperatively, except for physical and cognitive functioning in the conventional surgery group. Emotional functioning improved postoperatively in both groups compared to baseline. Conclusion—Despite a more extensive procedure with greater risk of morbidity, CRS-HIPEC in patients with colorectal peritoneal metastases did not have a greater negative impact on PROs than conventional surgery in patients with CRC. Further, systemic therapy did not affect these PROs. These findings may facilitate future patient counseling and shared decision making in clinical practice.

Originele taal-2	Engels
Artikelnummer	788
Aantal pagina's	14
Tijdschrift	Cancers
Volume	15
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.3390/cancers15030788
Status	Gepubliceerd - feb. 2023
Extern gepubliceerd	Ja

Financiering

De Hingh: An unrestricted research grant from RanD/QP&S and Roche, paid to the institute, unrelated to the submitted work. All other authors did not have any disclosures. The CAIRO6 trial is funded by the Dutch Cancer Society (grant number 10795) and F. Hoffman-La Roche (grant number ML39718). The PROCORE study was funded by the Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands; the Center of Research on Psychological and Somatic Disorders (CoRPS), Tilburg University, the Netherlands; and an Investment Grant Large of the Dutch Research Council (2016/04981/ZONMW-91101002). The funders had no role in study design, in the collection, analysis, and interpretation of data, in the writing of the report, and in the decision to submit the article for publication.

Financiers	Financiernummer
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	2016/04981/ZONMW-91101002
Tilburg University Tranzo

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10.3390/cancers15030788

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Bakkers, C., van de Vlasakker, V. C. J., Rovers, K. P. B., Lurvink, R. J., Nienhuijs, S. W., Burger, J. W. A., Creemers, G. J. M., Bonhof, C. S., Mols, F., & de Hingh, I. H. J. T. (2023). The Impact of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) versus Conventional Surgery on Patient-Reported Outcomes: A Comparative Cohort Study between the CAIRO6 Trial and the PROCORE Study. Cancers, 15(3), Artikel 788. https://doi.org/10.3390/cancers15030788

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title = "The Impact of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) versus Conventional Surgery on Patient-Reported Outcomes: A Comparative Cohort Study between the CAIRO6 Trial and the PROCORE Study",

abstract = "Purpose—To compare patient-reported outcomes (PROs) of patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for colorectal peritoneal metastases to PROs of colorectal cancer (CRC) patients undergoing conventional surgery. Methods—Data were extracted from the CAIRO6 trial (CRS-HIPEC group) and the PROCORE study (conventional surgery group). Nine predefined PROs (derived from the EORTC QLQ-C30 questionnaire) were compared at baseline, in the early postoperative period and one year postoperatively, with correction for treatment with systemic therapy using linear mixed modeling. Results—In total, 331 patients were included: 71 in the CRS-HIPEC group and 260 in the conventional surgery group. All predefined PROs (fatigue, diarrhea, C30 summary score, Global Health Status, physical, role, emotional, cognitive, and social functioning) did not differ significantly between the groups at all three timepoints, and differential effects over time for all PROs did not differ significantly between the groups. Significant worsening of fatigue, C30 summary score, physical and role functioning (both groups), and cognitive and social functioning (conventional surgery group only) was present in the early postoperative period. All scores returned to baseline at one year postoperatively, except for physical and cognitive functioning in the conventional surgery group. Emotional functioning improved postoperatively in both groups compared to baseline. Conclusion—Despite a more extensive procedure with greater risk of morbidity, CRS-HIPEC in patients with colorectal peritoneal metastases did not have a greater negative impact on PROs than conventional surgery in patients with CRC. Further, systemic therapy did not affect these PROs. These findings may facilitate future patient counseling and shared decision making in clinical practice.",

keywords = "colorectal neoplasms, CRS-HIPEC, cytoreduction, patient-reported outcome measures, peritoneal neoplasms, quality of life, surgical procedures",

author = "Checca Bakkers and \{van de Vlasakker\}, \{Vincent C.J.\} and Rovers, \{Koen P.B.\} and Lurvink, \{Robin J.\} and Nienhuijs, \{Simon W.\} and Burger, \{Jacobus W.A.\} and Creemers, \{Geert Jan M.\} and Bonhof, \{Cynthia S.\} and Floortje Mols and \{de Hingh\}, \{Ignace H.J.T.\}",

year = "2023",

month = feb,

doi = "10.3390/cancers15030788",

language = "English",

volume = "15",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

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Bakkers, C, van de Vlasakker, VCJ, Rovers, KPB, Lurvink, RJ, Nienhuijs, SW, Burger, JWA, Creemers, GJM, Bonhof, CS, Mols, F & de Hingh, IHJT 2023, 'The Impact of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) versus Conventional Surgery on Patient-Reported Outcomes: A Comparative Cohort Study between the CAIRO6 Trial and the PROCORE Study', Cancers, vol. 15, nr. 3, 788. https://doi.org/10.3390/cancers15030788

The Impact of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) versus Conventional Surgery on Patient-Reported Outcomes: A Comparative Cohort Study between the CAIRO6 Trial and the PROCORE Study. / Bakkers, Checca; van de Vlasakker, Vincent C.J.; Rovers, Koen P.B. et al.
In: Cancers, Vol. 15, Nr. 3, 788, 02.2023.

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

TY - JOUR

T1 - The Impact of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) versus Conventional Surgery on Patient-Reported Outcomes

T2 - A Comparative Cohort Study between the CAIRO6 Trial and the PROCORE Study

AU - Bakkers, Checca

AU - van de Vlasakker, Vincent C.J.

AU - Rovers, Koen P.B.

AU - Lurvink, Robin J.

AU - Nienhuijs, Simon W.

AU - Burger, Jacobus W.A.

AU - Creemers, Geert Jan M.

AU - Bonhof, Cynthia S.

AU - Mols, Floortje

AU - de Hingh, Ignace H.J.T.

PY - 2023/2

Y1 - 2023/2

N2 - Purpose—To compare patient-reported outcomes (PROs) of patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for colorectal peritoneal metastases to PROs of colorectal cancer (CRC) patients undergoing conventional surgery. Methods—Data were extracted from the CAIRO6 trial (CRS-HIPEC group) and the PROCORE study (conventional surgery group). Nine predefined PROs (derived from the EORTC QLQ-C30 questionnaire) were compared at baseline, in the early postoperative period and one year postoperatively, with correction for treatment with systemic therapy using linear mixed modeling. Results—In total, 331 patients were included: 71 in the CRS-HIPEC group and 260 in the conventional surgery group. All predefined PROs (fatigue, diarrhea, C30 summary score, Global Health Status, physical, role, emotional, cognitive, and social functioning) did not differ significantly between the groups at all three timepoints, and differential effects over time for all PROs did not differ significantly between the groups. Significant worsening of fatigue, C30 summary score, physical and role functioning (both groups), and cognitive and social functioning (conventional surgery group only) was present in the early postoperative period. All scores returned to baseline at one year postoperatively, except for physical and cognitive functioning in the conventional surgery group. Emotional functioning improved postoperatively in both groups compared to baseline. Conclusion—Despite a more extensive procedure with greater risk of morbidity, CRS-HIPEC in patients with colorectal peritoneal metastases did not have a greater negative impact on PROs than conventional surgery in patients with CRC. Further, systemic therapy did not affect these PROs. These findings may facilitate future patient counseling and shared decision making in clinical practice.

AB - Purpose—To compare patient-reported outcomes (PROs) of patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for colorectal peritoneal metastases to PROs of colorectal cancer (CRC) patients undergoing conventional surgery. Methods—Data were extracted from the CAIRO6 trial (CRS-HIPEC group) and the PROCORE study (conventional surgery group). Nine predefined PROs (derived from the EORTC QLQ-C30 questionnaire) were compared at baseline, in the early postoperative period and one year postoperatively, with correction for treatment with systemic therapy using linear mixed modeling. Results—In total, 331 patients were included: 71 in the CRS-HIPEC group and 260 in the conventional surgery group. All predefined PROs (fatigue, diarrhea, C30 summary score, Global Health Status, physical, role, emotional, cognitive, and social functioning) did not differ significantly between the groups at all three timepoints, and differential effects over time for all PROs did not differ significantly between the groups. Significant worsening of fatigue, C30 summary score, physical and role functioning (both groups), and cognitive and social functioning (conventional surgery group only) was present in the early postoperative period. All scores returned to baseline at one year postoperatively, except for physical and cognitive functioning in the conventional surgery group. Emotional functioning improved postoperatively in both groups compared to baseline. Conclusion—Despite a more extensive procedure with greater risk of morbidity, CRS-HIPEC in patients with colorectal peritoneal metastases did not have a greater negative impact on PROs than conventional surgery in patients with CRC. Further, systemic therapy did not affect these PROs. These findings may facilitate future patient counseling and shared decision making in clinical practice.

KW - colorectal neoplasms

KW - CRS-HIPEC

KW - cytoreduction

KW - patient-reported outcome measures

KW - peritoneal neoplasms

KW - quality of life

KW - surgical procedures

UR - https://www.scopus.com/pages/publications/85147807172

U2 - 10.3390/cancers15030788

DO - 10.3390/cancers15030788

M3 - Article

C2 - 36765746

AN - SCOPUS:85147807172

SN - 2072-6694

VL - 15

JO - Cancers

JF - Cancers

IS - 3

M1 - 788

ER -

Bakkers C, van de Vlasakker VCJ, Rovers KPB, Lurvink RJ, Nienhuijs SW, Burger JWA et al. The Impact of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) versus Conventional Surgery on Patient-Reported Outcomes: A Comparative Cohort Study between the CAIRO6 Trial and the PROCORE Study. Cancers. 2023 feb.;15(3):788. doi: 10.3390/cancers15030788