The Impact of a Limited Field-of-View on Computed Hemodynamics in Abdominal Aortic Aneurysms: Evaluating the Feasibility of Completing Ultrasound Segmentations with Parametric Geometries

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Samenvatting

To improve abdominal aortic aneurysm (AAA) rupture risk assessment, a large, longitudinal study on AAA hemodynamics and biomechanics is necessary, using personalized fluid-structure interaction (FSI) modeling. 3-dimensional, time-resolved ultrasound (3D+t US) is the preferred image modality to obtain the patient-specific AAA geometry for such a study, since it is safe, affordable and provides temporal information. However, the 3D+t US field-of-view (FOV) is limited and therefore often fails to capture the inlet and aorto-iliac bifurcation geometry. In this study, a framework was developed to add parametric inlet and bifurcation geometries to the abdominal aortic aneurysm geometry by employing dataset statistics and parameters of the AAA geometry. The impact of replacing the patient-specific inlet and bifurcation geometries, acquired using computed tomography (CT) scans, by parametric geometries was evaluated by examining the differences in hemodynamics (systolic and time-averaged wall shear stress and oscillatory shear index) in the aneurysm region. The results show that the inlet geometry has a larger effect on the AAA hemodynamics (median differences of 7.5 to 18.8%) than the bifurcation geometry (median differences all below 1%). Therefore, it is not feasible to replace the patient-specific inlet geometry by a generic one. Future studies should investigate the possibilities of extending the proximal FOV of 3D+t US. However, this study did show the feasibility of adding a parametric bifurcation geometry to the aneurysm geometry. After extending the proximal FOV, the obtained framework can be used to extract AAA geometries from 3D+t US for FSI simulations, despite the absence of the bifurcation geometry.

Originele taal-2Engels
Pagina's (van-tot)1296-1309
Aantal pagina's14
TijdschriftAnnals of Biomedical Engineering
Volume51
Nummer van het tijdschrift6
DOI's
StatusGepubliceerd - jun. 2023

Bibliografische nota

Funding Information:
This work was supported by the Dutch Research Council (NWO) and received funding from the NWO talent program VIDI (17533, awarded to R.G.P. Lopata). All computational work was carried out on the Dutch national e-infrastructure with the support of SURF Cooperative. We want to thank ANSYS Inc for their valuable technical support.

Publisher Copyright:
© 2023, The Author(s).

Financiering

This work was supported by the Dutch Research Council (NWO) and received funding from the NWO talent program VIDI (17533, awarded to R.G.P. Lopata). All computational work was carried out on the Dutch national e-infrastructure with the support of SURF Cooperative. We want to thank ANSYS Inc for their valuable technical support.

FinanciersFinanciernummer
Surf, Stichting
Nederlandse Organisatie voor Wetenschappelijk Onderzoek17533

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