The enantioselective step in the nickel-catalyzed hydrocyanation of 1,3-cyclohexadiene

D. Vogt; J.B.M. Wilting; M.C.C. Janssen; C. Müller

doi:10.1021/ja064378u

The enantioselective step in the nickel-catalyzed hydrocyanation of 1,3-cyclohexadiene

D. Vogt
, J.B.M. Wilting
, M.C.C. Janssen
, C. Müller

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

62 Citaten (Scopus)

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On the basis of deuterium labeling experiments and an equal 1,2-/1,4-product distribution, the reductive elimination of the product has been established to be the enantioselective step in the nickel-catalyzed hydrocyanation of 1,3-cyclohexadiene. This could be achieved by successfully exploiting the rather unique features of this reaction: identical product formation for 1,2- and 1,4-addition, cis addition over the diene, and high enantiomeric excess.

Originele taal-2	Engels
Pagina's (van-tot)	11374-11375
Tijdschrift	Journal of the American Chemical Society
Volume	128
Nummer van het tijdschrift	35
DOI's	https://doi.org/10.1021/ja064378u
Status	Gepubliceerd - 2006

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10.1021/ja064378u

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title = "The enantioselective step in the nickel-catalyzed hydrocyanation of 1,3-cyclohexadiene",

abstract = "On the basis of deuterium labeling experiments and an equal 1,2-/1,4-product distribution, the reductive elimination of the product has been established to be the enantioselective step in the nickel-catalyzed hydrocyanation of 1,3-cyclohexadiene. This could be achieved by successfully exploiting the rather unique features of this reaction: identical product formation for 1,2- and 1,4-addition, cis addition over the diene, and high enantiomeric excess.",

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AU - Wilting, J.B.M.

AU - Janssen, M.C.C.

AU - Müller, C.

PY - 2006

Y1 - 2006

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AB - On the basis of deuterium labeling experiments and an equal 1,2-/1,4-product distribution, the reductive elimination of the product has been established to be the enantioselective step in the nickel-catalyzed hydrocyanation of 1,3-cyclohexadiene. This could be achieved by successfully exploiting the rather unique features of this reaction: identical product formation for 1,2- and 1,4-addition, cis addition over the diene, and high enantiomeric excess.

U2 - 10.1021/ja064378u

DO - 10.1021/ja064378u

M3 - Article

C2 - 16939259

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The enantioselective step in the nickel-catalyzed hydrocyanation of 1,3-cyclohexadiene

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