The diagnostic value of fetal fibronectin testing in clinical practice

Lisa Cornelissen (Corresponding author), Noortje H.M. van Oostrum, Daisy van der Woude, Christel Rollf, Martina M. Porath, S.G. (Guid) Oei, Judith O.E.H. van Laar

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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Samenvatting

Aim: To evaluate the clinical management to withhold treatment for preterm labor in symptomatic women with an intermediate cervical length and negative fetal fibronectin (fFN) testing. Methods: A retrospective cohort study was performed in a tertiary care teaching hospital in the Netherlands. Pregnant women with a gestational age between 23+5 to 34+0 weeks, with the presence of regular uterine contractions accompanied by a cervical length between 15 and 30 mm and intact membranes, who underwent fFN testing were included to obtain the diagnostic value of fFN testing for preterm delivery within 7 days. Results: Fetal fibronectin testing has an extremely high negative predictive value (100%) and sensitivity (100%) for delivery within 7 days, in singleton and multiple pregnancies. However, specificity (64%) and positive predictive value (10%) of fFN testing in singleton pregnancies are low. Blood present on the fFN sample does not affect the reliability of the fFN test; the negative predictive value remains 100%. Conclusion: Women with symptoms of early preterm labor, intact membranes, a cervical length between 15 and 30 mm and negative fFN testing do not deliver within 7 days. Administration of corticosteroids and tocolytics can safely be withhold. Furthermore, blood on the fFN sample does not change the reliability of the fFN test.

Originele taal-2Engels
Pagina's (van-tot)405-412
Aantal pagina's8
TijdschriftJournal of Obstetrics and Gynaecology Research
Volume46
Nummer van het tijdschrift3
DOI's
StatusGepubliceerd - 1 mrt 2020

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    Perinatal Medicine

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