The binding of CNA35 contrast agents to collagen fibrils

H.M.H.F. Sanders; M. Iafisco; E.M. Pouget; P.H.H. Bomans; F. Nudelman; G. Falini; G. With, de; M. Merkx; G.J. Strijkers; K. Nicolaij; N.A.J.M. Sommerdijk

doi:10.1039/c0cc02901g

The binding of CNA35 contrast agents to collagen fibrils

H.M.H.F. Sanders
, M. Iafisco
, E.M. Pouget
, P.H.H. Bomans
, F. Nudelman
, G. Falini
, G. With, de
, M. Merkx
, G.J. Strijkers
, K. Nicolaij
, N.A.J.M. Sommerdijk

Protein Engineering

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

24 Citaten (Scopus)

4 Downloads (Pure)

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CryoTEM demonstrates that a CNA35-bearing liposomal MRI contrast agent selectively binds to poorly assembled collagen type I as opposed to well-assembled collagen fibrils, whereas monomeric CNA35 binds to all forms of collagen. It is shown that upon conjugation to liposomes and micelles CNA35 loses its ability to dissociate ordered collagen fibrils and thereby to create its own binding sites.

Originele taal-2	Engels
Pagina's (van-tot)	1503-1505
Aantal pagina's	3
Tijdschrift	Chemical Communications, ChemComm
Volume	47
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1039/c0cc02901g
Status	Gepubliceerd - 2011

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10.1039/c0cc02901g

Center for Multiscale Electron Microscopy (CMEM)
Friedrich, H. (Manager), Bransen, M. (Education/onderzoek medewerker), Schmit, P. (Education/onderzoek medewerker), Schreur - Piet, I. (Inhoud) & Spoelstra, A. (Education/onderzoek medewerker)
Uitrusting/faciliteit: Onderzoekslaboratorium

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abstract = "CryoTEM demonstrates that a CNA35-bearing liposomal MRI contrast agent selectively binds to poorly assembled collagen type I as opposed to well-assembled collagen fibrils, whereas monomeric CNA35 binds to all forms of collagen. It is shown that upon conjugation to liposomes and micelles CNA35 loses its ability to dissociate ordered collagen fibrils and thereby to create its own binding sites.",

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AU - Nudelman, F.

AU - Falini, G.

AU - With, de, G.

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AU - Strijkers, G.J.

AU - Nicolaij, K.

AU - Sommerdijk, N.A.J.M.

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AB - CryoTEM demonstrates that a CNA35-bearing liposomal MRI contrast agent selectively binds to poorly assembled collagen type I as opposed to well-assembled collagen fibrils, whereas monomeric CNA35 binds to all forms of collagen. It is shown that upon conjugation to liposomes and micelles CNA35 loses its ability to dissociate ordered collagen fibrils and thereby to create its own binding sites.

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The binding of CNA35 contrast agents to collagen fibrils

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Center for Multiscale Electron Microscopy (CMEM)

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