System identification to analyse changed kinetics of SERCA in intact rat heart

Natal A.W. van Riel (Corresponding author), Tamas Ivanics, Laszlo Ligeti, Ger J. van der Vusse

Onderzoeksoutput: Bijdrage aan tijdschriftCongresartikelAcademicpeer review

3 Citaten (Scopus)


A mechanistic-based model has been derived of calcium handling in the intact heart. This model incorporates the quantitatively most important processes involved in beat-to-beat calcium homeostasis. Based on a priori physiological information the model has been reduced to yield (kinetic) parameters that could be estimated using time-series data of the free calcium concentration in the sarcoplasma. Observations of the dynamics of the overall system were translated into the underlying mechanisms. Experiments in which the most important calcium extrusion pump (Sarcoplasmic Reticulum Ca 2+ -ATPase, SERCA) was disturbed have been successfully analysed and interpreted using model and identification.

Originele taal-2Engels
Pagina's (van-tot)125-128
Aantal pagina's4
TijdschriftIFAC Proceedings Volumes
Nummer van het tijdschrift15
StatusGepubliceerd - 1 jan 2003
Evenement5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003 - Melbourne, Australië
Duur: 21 aug 200323 aug 2003

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