A mechanistic-based model has been derived of calcium handling in the intact heart. This model incorporates the quantitatively most important processes involved in beat-to-beat calcium homeostasis. Based on a priori physiological information the model has been reduced to yield (kinetic) parameters that could be estimated using time-series data of the free calcium concentration in the sarcoplasma. Observations of the dynamics of the overall system were translated into the underlying mechanisms. Experiments in which the most important calcium extrusion pump (Sarcoplasmic Reticulum Ca 2+ -ATPase, SERCA) was disturbed have been successfully analysed and interpreted using model and identification.
|Tijdschrift||IFAC Proceedings Volumes|
|Nummer van het tijdschrift||15|
|Status||Gepubliceerd - 1 jan 2003|
|Evenement||5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003 - Melbourne, Australië|
Duur: 21 aug 2003 → 23 aug 2003