Synthetic pathways to tetrahydrocannabinol (THC): an overview

Victor R.L.J. Bloemendal, Jan C.M. van Hest, Floris P.J.T. Rutjes (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

4 Citaten (Scopus)


The therapeutic effects of molecules produced by the plant speciesCannabis sativahave since their discovery captured the interest of scientists and society, and have spurred the development of a multidisciplinary scientific field with contributions from biologists, medical specialists and chemists. Decades after the first isolation of some of the most bioactive tetrahydrocannabinols, current research is mostly dedicated to exploiting the chemical versatility of this relevant compound class with regard to its therapeutic potential. This review will primarily focus on synthetic pathways utilised for the synthesis of tetrahydrocannabinols and derivatives thereof, including chiral pool-based and asymmetric chemo- and biocatalytic approaches.

Originele taal-2Engels
Pagina's (van-tot)3203-3215
Aantal pagina's13
TijdschriftOrganic and Biomolecular Chemistry
Nummer van het tijdschrift17
StatusGepubliceerd - 7 mei 2020

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