Supramolecular control of enzyme activity through cucurbit[8]uril mediated dimerization

T.D. Dang; H. Nguyen; M. Merkx; L. Brunsveld

doi:10.1002/anie.201208239

Supramolecular control of enzyme activity through cucurbit[8]uril mediated dimerization

T.D. Dang
, H. Nguyen
, M. Merkx
, L. Brunsveld

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

107 Citaten (Scopus)

5 Downloads (Pure)

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At the double: Cucurbit[8]uril-mediated protein dimerization enables reversible control over strong enzyme activation of caspases. Simple addition of a short N-terminal FGG motif allows for a supramolecular-mediated 50-fold enhancement of caspase-9 catalytic activity.

Originele taal-2	Engels
Pagina's (van-tot)	2915-2919
Aantal pagina's	4
Tijdschrift	Angewandte Chemie - International Edition
Volume	52
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.1002/anie.201208239
Status	Gepubliceerd - 2013

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10.1002/anie.201208239

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title = "Supramolecular control of enzyme activity through cucurbit[8]uril mediated dimerization",

abstract = "At the double: Cucurbit[8]uril-mediated protein dimerization enables reversible control over strong enzyme activation of caspases. Simple addition of a short N-terminal FGG motif allows for a supramolecular-mediated 50-fold enhancement of caspase-9 catalytic activity.",

author = "T.D. Dang and H. Nguyen and M. Merkx and L. Brunsveld",

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DO - 10.1002/anie.201208239

M3 - Article

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Supramolecular control of enzyme activity through cucurbit[8]uril mediated dimerization

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