Study of petrolatum structure: explaining its variable rheological behavior

A.J.P. van Heugten; J. Landman; A.V. Petukhov; H. Vromans

doi:10.1016/j.ijpharm.2018.02.016

Study of petrolatum structure: explaining its variable rheological behavior

A.J.P. van Heugten
, J. Landman
, A.V. Petukhov
, H. Vromans

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

18 Citaten (Scopus)

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The rheological properties of petrolatum are dependent on both temperature and thermal history. How this thermal dependency can be explained is unclear. In the past it has been suggested that the structure of petrolatum consists of a three-dimensional crystalline network. This has been established using old microscopic techniques only. Therefore a study on the microstructure of petrolatum was conducted using rheometry, DSC, pulsed NMR, polarized light microscopy and synchrotron X-ray. The combination of these techniques show that petrolatum is composed of 21% solid material at room temperature. This consists of partly crystalline lamellar sheets which are packed in stacks. The occurrence of these lamellar sheets is temperature dependent and the number of lamellar stacks is dependent on thermal history. It was shown that rheological differences in petrolatum can be explained by the number of lamellar stacks present, where more lamellar stacks result in more rigid petrolatum.

Originele taal-2	Engels
Pagina's (van-tot)	178-184
Aantal pagina's	7
Tijdschrift	International Journal of Pharmaceutics
Volume	540
Nummer van het tijdschrift	1-2
DOI's	https://doi.org/10.1016/j.ijpharm.2018.02.016
Status	Gepubliceerd - 5 apr. 2018

Financiering

We thank Samia Ouhajji, Carla Fernàndez-Rico and Daniel Hermida-Merino for their help during synchrotron measurements. The Netherlands Organisation of Scientific Research (NWO) is acknowledged for the allocation of beamtime at DUBBLE at ESRF – the European Synchrotron. This work was supported by the R&D tax credit of the Ministry of Economic Affairs , The Netherlands (grant S016053527 ). JL acknowledges financial support from NWO (grant 022.004.016 ) and the ESRF .

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10.1016/j.ijpharm.2018.02.016

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title = "Study of petrolatum structure: explaining its variable rheological behavior",

abstract = "The rheological properties of petrolatum are dependent on both temperature and thermal history. How this thermal dependency can be explained is unclear. In the past it has been suggested that the structure of petrolatum consists of a three-dimensional crystalline network. This has been established using old microscopic techniques only. Therefore a study on the microstructure of petrolatum was conducted using rheometry, DSC, pulsed NMR, polarized light microscopy and synchrotron X-ray. The combination of these techniques show that petrolatum is composed of 21\% solid material at room temperature. This consists of partly crystalline lamellar sheets which are packed in stacks. The occurrence of these lamellar sheets is temperature dependent and the number of lamellar stacks is dependent on thermal history. It was shown that rheological differences in petrolatum can be explained by the number of lamellar stacks present, where more lamellar stacks result in more rigid petrolatum.",

keywords = "Microstructure, Nanostructure, Petrolatum, Rheology, Synchrotron X-ray, Technology, Pharmaceutical/methods, Temperature, Excipients/chemistry, Magnetic Resonance Spectroscopy, Petrolatum/chemistry, Crystallization, Microscopy, Polarization, Scattering, Small Angle, Structure-Activity Relationship, Synchrotrons, X-Ray Diffraction, Drug Compounding, Calorimetry, Differential Scanning, Molecular Structure",

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AU - Petukhov, A.V.

AU - Vromans, H.

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AB - The rheological properties of petrolatum are dependent on both temperature and thermal history. How this thermal dependency can be explained is unclear. In the past it has been suggested that the structure of petrolatum consists of a three-dimensional crystalline network. This has been established using old microscopic techniques only. Therefore a study on the microstructure of petrolatum was conducted using rheometry, DSC, pulsed NMR, polarized light microscopy and synchrotron X-ray. The combination of these techniques show that petrolatum is composed of 21% solid material at room temperature. This consists of partly crystalline lamellar sheets which are packed in stacks. The occurrence of these lamellar sheets is temperature dependent and the number of lamellar stacks is dependent on thermal history. It was shown that rheological differences in petrolatum can be explained by the number of lamellar stacks present, where more lamellar stacks result in more rigid petrolatum.

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KW - Nanostructure

KW - Petrolatum

KW - Rheology

KW - Synchrotron X-ray

KW - Technology, Pharmaceutical/methods

KW - Temperature

KW - Excipients/chemistry

KW - Magnetic Resonance Spectroscopy

KW - Petrolatum/chemistry

KW - Crystallization

KW - Microscopy, Polarization

KW - Scattering, Small Angle

KW - Structure-Activity Relationship

KW - Synchrotrons

KW - X-Ray Diffraction

KW - Drug Compounding

KW - Calorimetry, Differential Scanning

KW - Molecular Structure

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Study of petrolatum structure: explaining its variable rheological behavior

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