TY - GEN
T1 - Structural effects of small molecules on phospholipid bilayers investigated by molecular simulations
AU - Lee, B.W.
AU - Faller, R.
AU - Sum, A.K.
AU - Vattulainen, I.
AU - Patra, M.
AU - Karttunen, M.E.J.
PY - 2005
Y1 - 2005
N2 - We summarize and compare recent molecular dynamics simulations on the interactions of dipalmitoylphosphatidylcholine (DPPC) bilayers in the liquid crystalline phase with a number of small molecules including trehalose, a disaccharide of glucose, alcohols, and dimethylsulfoxide (DMSO). The sugar molecules tend to stabilize the structure of the bilayer as they bridge adjacent lipid headgroups. They do not strongly change the structure of the bilayer. Alcohols and DMSO destabilize the bilayer as they increase its area per molecule in the bilayer plane and decrease the order parameter. Alcohols have a stronger detrimental effect than DMSO. The observables which we compare are the area per molecule in the plane of the bilayer, the membrane thickness, and the nuclear magnetic resonance (NMR) order parameter of DPPC hydrocarbon tails. The area per molecule and the order parameter are very well correlated whereas the bilayer thickness is not necessarily correlated with them.
Abbreviations: DMSO, dimethylsulfoxide; DPPC, dipalmitoylphosphatidylcholine; GROMOS, Groningen molecular simulation; NERD, Nath, Escobedo and de Pablo revised force-field; NMR, nuclear magnetic resonance; PME, particle mesh Ewald; SOPC, stearoyloleoylphosphatidylcholine
Keywords: Lipid membranes; Structure and physical properties; Theory and modeling; Molecular simulation
AB - We summarize and compare recent molecular dynamics simulations on the interactions of dipalmitoylphosphatidylcholine (DPPC) bilayers in the liquid crystalline phase with a number of small molecules including trehalose, a disaccharide of glucose, alcohols, and dimethylsulfoxide (DMSO). The sugar molecules tend to stabilize the structure of the bilayer as they bridge adjacent lipid headgroups. They do not strongly change the structure of the bilayer. Alcohols and DMSO destabilize the bilayer as they increase its area per molecule in the bilayer plane and decrease the order parameter. Alcohols have a stronger detrimental effect than DMSO. The observables which we compare are the area per molecule in the plane of the bilayer, the membrane thickness, and the nuclear magnetic resonance (NMR) order parameter of DPPC hydrocarbon tails. The area per molecule and the order parameter are very well correlated whereas the bilayer thickness is not necessarily correlated with them.
Abbreviations: DMSO, dimethylsulfoxide; DPPC, dipalmitoylphosphatidylcholine; GROMOS, Groningen molecular simulation; NERD, Nath, Escobedo and de Pablo revised force-field; NMR, nuclear magnetic resonance; PME, particle mesh Ewald; SOPC, stearoyloleoylphosphatidylcholine
Keywords: Lipid membranes; Structure and physical properties; Theory and modeling; Molecular simulation
U2 - 10.1016/j.fluid.2005.03.002
DO - 10.1016/j.fluid.2005.03.002
M3 - Conference contribution
T3 - Fluid Phase Equilibria
SP - 135
EP - 140
BT - PPEPPD 2004 Proceedings
A2 - Cummings, P.T.
A2 - O'Connell, J.P.
T2 - conference; PPEPPD 2004
Y2 - 1 January 2005
ER -