Uittreksel

The cytoskeleton is a highly adaptive network of filamentous proteins capable of stiffening under stress even as it dynamically assembles and disassembles with time constants of minutes. Synthetic materials that combine reversibility and strain-stiffening properties remain elusive. Here, strain-stiffening hydrogels that have dynamic fibrous polymers as their main structural components are reported. The fibers form via self-assembly of bolaamphiphiles (BA) in water and have a well-defined cross-section of 9 to 10 molecules. Fiber length recovery after sonication, H/D exchange experiments, and rheology confirm the dynamic nature of the fibers. Cross-linking of the fibers yields strain-stiffening, self-healing hydrogels that closely mimic the mechanics of biological networks, with mechanical properties that can be modulated by chemical modification of the components. Comparison of the supramolecular networks with covalently fixated networks shows that the noncovalent nature of the fibers limits the maximum stress that fibers can bear and, hence, limits the range of stiffening.

TaalEngels
Pagina's17547-17555
Aantal pagina's9
TijdschriftJournal of the American Chemical Society
Volume140
Nummer van het tijdschrift50
DOI's
StatusGepubliceerd - 19 dec 2018

Vingerafdruk

Hydrogels
Stress Fibers
Sonication
Fibers
Rheology
Mechanics
Cytoskeleton
Polymers
Water
Proteins
Chemical modification
Self assembly
Recovery
Mechanical properties
Molecules
bolaamphiphile
Experiments

Citeer dit

@article{6f565425506e49958d4f2cd3ba185203,
title = "Strain-stiffening in dynamic supramolecular fiber networks",
abstract = "The cytoskeleton is a highly adaptive network of filamentous proteins capable of stiffening under stress even as it dynamically assembles and disassembles with time constants of minutes. Synthetic materials that combine reversibility and strain-stiffening properties remain elusive. Here, strain-stiffening hydrogels that have dynamic fibrous polymers as their main structural components are reported. The fibers form via self-assembly of bolaamphiphiles (BA) in water and have a well-defined cross-section of 9 to 10 molecules. Fiber length recovery after sonication, H/D exchange experiments, and rheology confirm the dynamic nature of the fibers. Cross-linking of the fibers yields strain-stiffening, self-healing hydrogels that closely mimic the mechanics of biological networks, with mechanical properties that can be modulated by chemical modification of the components. Comparison of the supramolecular networks with covalently fixated networks shows that the noncovalent nature of the fibers limits the maximum stress that fibers can bear and, hence, limits the range of stiffening.",
author = "{Fern{\'a}ndez-Casta{\~n}o Romera}, Marcos and Xianwen Lou and Jurgen Schill and {ter Huurne}, Gijs and Fransen, {Peter Paul K.H.} and Voets, {Ilja K.} and Cornelis Storm and Sijbesma, {Rint P.}",
year = "2018",
month = "12",
day = "19",
doi = "10.1021/jacs.8b09289",
language = "English",
volume = "140",
pages = "17547--17555",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "50",

}

TY - JOUR

T1 - Strain-stiffening in dynamic supramolecular fiber networks

AU - Fernández-Castaño Romera,Marcos

AU - Lou,Xianwen

AU - Schill,Jurgen

AU - ter Huurne,Gijs

AU - Fransen,Peter Paul K.H.

AU - Voets,Ilja K.

AU - Storm,Cornelis

AU - Sijbesma,Rint P.

PY - 2018/12/19

Y1 - 2018/12/19

N2 - The cytoskeleton is a highly adaptive network of filamentous proteins capable of stiffening under stress even as it dynamically assembles and disassembles with time constants of minutes. Synthetic materials that combine reversibility and strain-stiffening properties remain elusive. Here, strain-stiffening hydrogels that have dynamic fibrous polymers as their main structural components are reported. The fibers form via self-assembly of bolaamphiphiles (BA) in water and have a well-defined cross-section of 9 to 10 molecules. Fiber length recovery after sonication, H/D exchange experiments, and rheology confirm the dynamic nature of the fibers. Cross-linking of the fibers yields strain-stiffening, self-healing hydrogels that closely mimic the mechanics of biological networks, with mechanical properties that can be modulated by chemical modification of the components. Comparison of the supramolecular networks with covalently fixated networks shows that the noncovalent nature of the fibers limits the maximum stress that fibers can bear and, hence, limits the range of stiffening.

AB - The cytoskeleton is a highly adaptive network of filamentous proteins capable of stiffening under stress even as it dynamically assembles and disassembles with time constants of minutes. Synthetic materials that combine reversibility and strain-stiffening properties remain elusive. Here, strain-stiffening hydrogels that have dynamic fibrous polymers as their main structural components are reported. The fibers form via self-assembly of bolaamphiphiles (BA) in water and have a well-defined cross-section of 9 to 10 molecules. Fiber length recovery after sonication, H/D exchange experiments, and rheology confirm the dynamic nature of the fibers. Cross-linking of the fibers yields strain-stiffening, self-healing hydrogels that closely mimic the mechanics of biological networks, with mechanical properties that can be modulated by chemical modification of the components. Comparison of the supramolecular networks with covalently fixated networks shows that the noncovalent nature of the fibers limits the maximum stress that fibers can bear and, hence, limits the range of stiffening.

UR - http://www.scopus.com/inward/record.url?scp=85058546646&partnerID=8YFLogxK

U2 - 10.1021/jacs.8b09289

DO - 10.1021/jacs.8b09289

M3 - Article

VL - 140

SP - 17547

EP - 17555

JO - Journal of the American Chemical Society

T2 - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 50

ER -