Social relationships and risk of dementia : a systematic review and meta-analysis of longitudinal cohort studies

J.S. Kuiper, M. Zuidersma, R.C. Oude Voshaar, S.U. Zuidema, E.R. Heuvel, van den, R.P. Stolk, N. Smidt

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

243 Citaten (Scopus)
3 Downloads (Pure)


It is unclear to what extent poor social relationships are related to the development of dementia. A comprehensive systematic literature search identified 19 longitudinal cohort studies investigating the association between various social relationship factors and incident dementia in the general population. Relative risks (RRs) with 95% confidence intervals (CIs) were pooled using random-effects meta-analysis. Low social participation (RR: 1.41 (95% CI: 1.13–1.75)), less frequent social contact (RR: 1.57 (95% CI: 1.32–1.85)), and more loneliness (RR: 1.58 (95% CI: 1.19–2.09)) were statistically significant associated with incident dementia. The results of the association between social network size and dementia were inconsistent. No statistically significant association was found for low satisfaction with social network and the onset of dementia (RR: 1.25 (95% CI: 0.96–1.62). We conclude that social relationship factors that represent a lack of social interaction are associated with incident dementia. The strength of the associations between poor social interaction and incident dementia is comparable with other well-established risk factors for dementia, including low education attainment, physical inactivity, and late-life depression. Keywords: Dementia; Social network; Social participation; Loneliness; Social contact; Social relationships
Originele taal-2Engels
Pagina's (van-tot)39-57
Aantal pagina's19
TijdschriftAgeing Research Reviews
StatusGepubliceerd - 2015

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