Small-molecule Modulators of Protein-Protein Interactions: Focus on 14-3-3 PPIs

L. Iralde-Lorente, M. Botta, C. Ottmann

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademicpeer review

Samenvatting

Small-molecule modulation of protein-protein interactions (PPIs) is one of the most promising approaches for drug discovery and chemical biology. In this chapter we give a brief overview of some important concepts and examples with a focus on modulators of binding of the adaptor protein 14-3-3 to its multitude of targets, many of which are of high medical relevance.

Originele taal-2Engels
TitelProtein Degradation with New Chemical Modalities
SubtitelSuccessful Strategies in Drug Discovery and Chemical Biology
RedacteurenSiddhartha Roy, Haian Fu
UitgeverijRoyal Society of Chemistry
Hoofdstuk10
Pagina's249-279
Aantal pagina's31
Uitgave78
ISBN van elektronische versie9781788011877, 9781788015479, 9781788016865, 9781788018012, 9781788018760
DOI's
StatusGepubliceerd - 2021

Publicatie series

NaamRSC Drug Discovery Series
Nummer78
ISSN van geprinte versie2041-3203
ISSN van elektronische versie2041-3211

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