Small animal cardiovascular MR imaging and spectroscopy

Ot Bakermans, D. Abdurrachim, R.P.M. Moonen, A.G. Motaal, J.J. Prompers, G.J. Strijkers, K. Vandoorne, K. Nicolay

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

16 Citaties (Scopus)

Uittreksel

The use of MR imaging and spectroscopy for studying cardiovascular disease processes in small animals has increased tremendously over the past decade. This is the result of the remarkable advances in MR technologies and the increased availability of genetically modified mice. MR techniques provide a window on the entire timeline of cardiovascular disease development, ranging from subtle early changes in myocardial metabolism that often mark disease onset to severe myocardial dysfunction associated with end-stage heart failure. MR imaging and spectroscopy techniques play an important role in basic cardiovascular research and in cardiovascular disease diagnosis and therapy follow-up. This is due to the broad range of functional, structural and metabolic parameters that can be quantified by MR under in vivo conditions non-invasively. This review describes the spectrum of MR techniques that are employed in small animal cardiovascular disease research and how the technological challenges resulting from the small dimensions of heart and blood vessels as well as high heart and respiratory rates, particularly in mice, are tackled.

TaalEngels
Pagina's1-47
Aantal pagina's47
TijdschriftProgress in Nuclear Magnetic Resonance Spectroscopy
Volume88-89
DOI's
StatusGepubliceerd - 1 aug 2015

Vingerafdruk

animals
Animals
Cardiovascular Diseases
Magnetic Resonance Spectroscopy
Spectroscopy
Imaging techniques
spectroscopy
mice
respiratory rate
Animal Diseases
Respiratory Rate
heart rate
Research
blood vessels
Blood Vessels
Blood vessels
metabolism
Metabolism
Heart Failure
imaging techniques

Trefwoorden

    Citeer dit

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    Small animal cardiovascular MR imaging and spectroscopy. / Bakermans, Ot; Abdurrachim, D.; Moonen, R.P.M.; Motaal, A.G.; Prompers, J.J.; Strijkers, G.J.; Vandoorne, K.; Nicolay, K.

    In: Progress in Nuclear Magnetic Resonance Spectroscopy, Vol. 88-89, 01.08.2015, blz. 1-47.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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