Shape-specific microfabricated particles for biomedical applications: a review

Thomas L. Moore (Corresponding author), Alexander B. Cook, Elena Belotti, Roberto Palomba, Purnima Manghnani, Raffaele Spano, Sayanti Brahmachari, Martina Di Francesco, Anna Lisa Palange, Daniele Di Mascolo, Paolo Decuzzi

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

5 Citaten (Scopus)
16 Downloads (Pure)


The storied history of controlled the release systems has evolved over time; from degradable drug-loaded sutures to monolithic zero-ordered release devices and nano-sized drug delivery formulations. Scientists have tuned the physico-chemical properties of these drug carriers to optimize their performance in biomedical/pharmaceutical applications. In particular, particle drug delivery systems at the micron size regime have been used since the 1980s. Recent advances in micro and nanofabrication techniques have enabled precise control of particle size and geometry–here we review the utility of microplates and discoidal polymeric particles for a range of pharmaceutical applications. Microplates are defined as micrometer scale polymeric local depot devices in cuboid form, while discoidal polymeric nanoconstructs are disk-shaped polymeric particles having a cross-sectional diameter in the micrometer range and a thickness in the hundreds of nanometer range. These versatile particles can be used to treat several pathologies such as cancer, inflammatory diseases and vascular diseases, by leveraging their size, shape, physical properties (e.g., stiffness), and component materials, to tune their functionality. This review highlights design and fabrication strategies for these particles, discusses their applications, and elaborates on emerging trends for their use in formulations.
Originele taal-2Engels
Pagina's (van-tot)2019-2037
Aantal pagina's19
TijdschriftDrug Delivery and Translational Research
Nummer van het tijdschrift8
StatusGepubliceerd - aug. 2022


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