Shape modulation of squaramide-based supramolecular polymer nanoparticles

Victorio Saez Talens, D.M.M. Makurat, Tingxian Liu, Wei Dai, Clément Guibert, Willem E.M. Noteborn, Ilja K. Voets, Roxanne E. Kieltyka (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Uittreksel

We report the synthesis and self-assembly of a library of squaramide-based bolaamphiphiles with variable hydrophobic and hydrophilic domain sizes, consisting of varied aliphatic chains (n = 2 to 12 methylene repeat units) and linear oligo(ethylene glycol) (m = 11 to 36 repeat units), to understand their effect on the formation of supramolecular polymer nanoparticles. Systematic variation of the hydrophobic chain length show that a minimum hydrophobic domain is required to shield the squaramide units from water when a constant hydrophilic domain is maintained for self-assembly. By contrast, significant increases to the hydrophilic chain length of the bolaamphiphile, while keeping the hydrophobic domain constant, results in a transition from fibrillar to spherical nanoscale objects with an alteration in the aggregation mode of the monomers likely due to steric constraints of the oligo(ethylene glycol) chains. By understanding the self-assembly space achievable for these squaramide-based bolaamphiphiles through examining the interplay between various monomer features, we show their distinct effects on the formation of self-assembled nanoparticles with possibilities to modulate their shape and size in water for future applications in the biomedical area.

TaalEngels
Pagina's3146-3153
Aantal pagina's8
TijdschriftPolymer Chemistry
Volume10
Nummer van het tijdschrift23
DOI's
StatusGepubliceerd - 21 jun 2019

Vingerafdruk

Nanoparticles
Self assembly
Polymers
Ethylene Glycol
Modulation
Ethylene glycol
Chain length
Monomers
Water
Self Report
Libraries
Agglomeration
bolaamphiphile
squaramide

Citeer dit

Saez Talens, V., Makurat, D. M. M., Liu, T., Dai, W., Guibert, C., Noteborn, W. E. M., ... Kieltyka, R. E. (2019). Shape modulation of squaramide-based supramolecular polymer nanoparticles. Polymer Chemistry, 10(23), 3146-3153. DOI: 10.1039/c9py00310j
Saez Talens, Victorio ; Makurat, D.M.M. ; Liu, Tingxian ; Dai, Wei ; Guibert, Clément ; Noteborn, Willem E.M. ; Voets, Ilja K. ; Kieltyka, Roxanne E./ Shape modulation of squaramide-based supramolecular polymer nanoparticles. In: Polymer Chemistry. 2019 ; Vol. 10, Nr. 23. blz. 3146-3153
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abstract = "We report the synthesis and self-assembly of a library of squaramide-based bolaamphiphiles with variable hydrophobic and hydrophilic domain sizes, consisting of varied aliphatic chains (n = 2 to 12 methylene repeat units) and linear oligo(ethylene glycol) (m = 11 to 36 repeat units), to understand their effect on the formation of supramolecular polymer nanoparticles. Systematic variation of the hydrophobic chain length show that a minimum hydrophobic domain is required to shield the squaramide units from water when a constant hydrophilic domain is maintained for self-assembly. By contrast, significant increases to the hydrophilic chain length of the bolaamphiphile, while keeping the hydrophobic domain constant, results in a transition from fibrillar to spherical nanoscale objects with an alteration in the aggregation mode of the monomers likely due to steric constraints of the oligo(ethylene glycol) chains. By understanding the self-assembly space achievable for these squaramide-based bolaamphiphiles through examining the interplay between various monomer features, we show their distinct effects on the formation of self-assembled nanoparticles with possibilities to modulate their shape and size in water for future applications in the biomedical area.",
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Saez Talens, V, Makurat, DMM, Liu, T, Dai, W, Guibert, C, Noteborn, WEM, Voets, IK & Kieltyka, RE 2019, 'Shape modulation of squaramide-based supramolecular polymer nanoparticles' Polymer Chemistry, vol. 10, nr. 23, blz. 3146-3153. DOI: 10.1039/c9py00310j

Shape modulation of squaramide-based supramolecular polymer nanoparticles. / Saez Talens, Victorio; Makurat, D.M.M.; Liu, Tingxian; Dai, Wei; Guibert, Clément; Noteborn, Willem E.M.; Voets, Ilja K.; Kieltyka, Roxanne E. (Corresponding author).

In: Polymer Chemistry, Vol. 10, Nr. 23, 21.06.2019, blz. 3146-3153.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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AU - Makurat,D.M.M.

AU - Liu,Tingxian

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AU - Guibert,Clément

AU - Noteborn,Willem E.M.

AU - Voets,Ilja K.

AU - Kieltyka,Roxanne E.

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N2 - We report the synthesis and self-assembly of a library of squaramide-based bolaamphiphiles with variable hydrophobic and hydrophilic domain sizes, consisting of varied aliphatic chains (n = 2 to 12 methylene repeat units) and linear oligo(ethylene glycol) (m = 11 to 36 repeat units), to understand their effect on the formation of supramolecular polymer nanoparticles. Systematic variation of the hydrophobic chain length show that a minimum hydrophobic domain is required to shield the squaramide units from water when a constant hydrophilic domain is maintained for self-assembly. By contrast, significant increases to the hydrophilic chain length of the bolaamphiphile, while keeping the hydrophobic domain constant, results in a transition from fibrillar to spherical nanoscale objects with an alteration in the aggregation mode of the monomers likely due to steric constraints of the oligo(ethylene glycol) chains. By understanding the self-assembly space achievable for these squaramide-based bolaamphiphiles through examining the interplay between various monomer features, we show their distinct effects on the formation of self-assembled nanoparticles with possibilities to modulate their shape and size in water for future applications in the biomedical area.

AB - We report the synthesis and self-assembly of a library of squaramide-based bolaamphiphiles with variable hydrophobic and hydrophilic domain sizes, consisting of varied aliphatic chains (n = 2 to 12 methylene repeat units) and linear oligo(ethylene glycol) (m = 11 to 36 repeat units), to understand their effect on the formation of supramolecular polymer nanoparticles. Systematic variation of the hydrophobic chain length show that a minimum hydrophobic domain is required to shield the squaramide units from water when a constant hydrophilic domain is maintained for self-assembly. By contrast, significant increases to the hydrophilic chain length of the bolaamphiphile, while keeping the hydrophobic domain constant, results in a transition from fibrillar to spherical nanoscale objects with an alteration in the aggregation mode of the monomers likely due to steric constraints of the oligo(ethylene glycol) chains. By understanding the self-assembly space achievable for these squaramide-based bolaamphiphiles through examining the interplay between various monomer features, we show their distinct effects on the formation of self-assembled nanoparticles with possibilities to modulate their shape and size in water for future applications in the biomedical area.

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Saez Talens V, Makurat DMM, Liu T, Dai W, Guibert C, Noteborn WEM et al. Shape modulation of squaramide-based supramolecular polymer nanoparticles. Polymer Chemistry. 2019 jun 21;10(23):3146-3153. Beschikbaar vanaf, DOI: 10.1039/c9py00310j