Semi-synthesis of a protease-activatable collagen targeting probe

M. Breurken; E.H.M. Lempens; E.W. Meijer; M. Merkx

doi:10.1039/C1CC11964H

Semi-synthesis of a protease-activatable collagen targeting probe

M. Breurken, E.H.M. Lempens, E.W. Meijer, M. Merkx

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

8 Citaten (Scopus)

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A protease-activatable collagen targeting probe (proCNA35) is synthesized by conjugation of a synthetic collagen fragment to the collagen binding protein CNA35 via a protease-cleavable linker. Cleavage of the linker by MMP1 releases the intramolecular inhibition of the collagen binding site and restores its collagen binding capacity.

Originele taal-2	Engels
Pagina's (van-tot)	7998-8000
Aantal pagina's	3
Tijdschrift	Chemical Communications, ChemComm
Volume	47
Nummer van het tijdschrift	28
DOI's	https://doi.org/10.1039/C1CC11964H
Status	Gepubliceerd - 2011

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10.1039/C1CC11964H

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abstract = "A protease-activatable collagen targeting probe (proCNA35) is synthesized by conjugation of a synthetic collagen fragment to the collagen binding protein CNA35 via a protease-cleavable linker. Cleavage of the linker by MMP1 releases the intramolecular inhibition of the collagen binding site and restores its collagen binding capacity.",

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AB - A protease-activatable collagen targeting probe (proCNA35) is synthesized by conjugation of a synthetic collagen fragment to the collagen binding protein CNA35 via a protease-cleavable linker. Cleavage of the linker by MMP1 releases the intramolecular inhibition of the collagen binding site and restores its collagen binding capacity.

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Semi-synthesis of a protease-activatable collagen targeting probe

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