Self-healing biomaterials: from molecular concepts to clinical applications

Mani Diba, Sergio Spaans, Ke Ning, Bastiaan D. Ippel, Fang Yang, Bas Loomans, Patricia Y.W. Dankers, Sander C.G. Leeuwenburgh

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19 Citaten (Scopus)
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Biomaterials are being applied in increasingly complex areas such as tissue engineering, bioprinting, and regenerative medicine. For these applications, challenging-or even contradictory-combinations of biomaterial properties are often required which cannot be met by conventional biomaterials. During the past decade, several new concepts have been developed to render biomaterials self-healing, thereby offering new opportunities to improve the functionality of traditional biomaterials in terms of their mechanical, handling, and biological properties. Consequently, various types of self-healing polymeric, ceramic, or composite biomaterials have been developed. Nevertheless, despite the rapid emergence of the field of self-healing biomaterials, this field of research has not been reviewed during the recent years. Therefore, this article provides a critical overview of recent progress in the field of self-healing biomaterials research by discussing both extrinsic and intrinsic self-healing systems. While the extrinsic self-healing section focuses on self-healing dental materials and orthopedic bone cements that rely on release of healing liquids from embedded microcapsules, the section on intrinsic self-healing materials mainly discusses concepts for self-healing of polymeric biomaterials that are either hydrated (hydrogels) or nonhydrated (e.g., films and coatings). Finally, benefits of the self-healing feature for biomaterials are discussed, and directions for future research and developments are outlined.

Originele taal-2Engels
Aantal pagina's21
TijdschriftAdvanced Materials Interfaces
Nummer van het tijdschrift17
StatusGepubliceerd - 7 sep 2018

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  • Citeer dit

    Diba, M., Spaans, S., Ning, K., Ippel, B. D., Yang, F., Loomans, B., Dankers, P. Y. W., & Leeuwenburgh, S. C. G. (2018). Self-healing biomaterials: from molecular concepts to clinical applications. Advanced Materials Interfaces, 5(17), [1800118].