Samenvatting
Nanoparticles of calcium phosphate assemble spontaneously within a few seconds into hollow spheres with a diameter around 200–300 nm in the presence of dissolved amino acids and dipeptides. The process of formation was followed by cryo-transmission electron microscopy (cryoTEM), proving their hollow nature which was also confirmed by nano-indentation by atomic force microscopy (AFM). The hollow spheres were analyzed by scanning electron microscopy (SEM), dynamic light scattering (DLS), nanoparticle tracking analysis (NTA) and elemental analysis. The hollow spheres were moderately stable against heating and ultrasonication. A self-assembly of the primarily formed calcium phosphate nanoparticles around amino acid-rich domains in water is proposed. As this process was observed with different amino acids, it appears to be a more general phenomenon.
Originele taal-2 | Engels |
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Pagina's (van-tot) | 9219-9223 |
Aantal pagina's | 5 |
Tijdschrift | Journal of Materials Chemistry |
Volume | 21 |
Nummer van het tijdschrift | 25 |
DOI's | |
Status | Gepubliceerd - 2011 |
Vingerafdruk
Duik in de onderzoeksthema's van 'Self-assembly of calcium phosphate nanoparticles into hollow spheres induced by dissolved amino acids'. Samen vormen ze een unieke vingerafdruk.Uitrusting
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Center for Multiscale Electron Microscopy (CMEM)
Heiner Friedrich (Manager), Rick Joosten (Education/onderzoek medewerker), Pauline Schmit (Education/onderzoek medewerker), Ingeborg Schreur - Piet (Inhoud) & Anne Spoelstra (Education/onderzoek medewerker)
Physical ChemistryUitrusting/faciliteit: Onderzoekslaboratorium