Selective C(sp3)−H aerobic oxidation enabled by decatungstate photocatalysis in flow

G. Laudadio, S. Govaerts, Y. Wang, D. Ravelli, H. Koolman, M. Fagnoni, S. Djuric, T. Noel

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

50 Citaten (Scopus)
79 Downloads (Pure)

Samenvatting

A mild and selective C(sp3)−H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and enhanced irradiation of the reaction mixture. Our method allows for the oxidation of both activated and unactivated C−H bonds (30 examples). The ability to selectively oxidize natural scaffolds, such as (−)-ambroxide, pregnenolone acetate, (+)-sclareolide, and artemisinin, exemplifies the utility of this new method.

Originele taal-2Engels
Pagina's (van-tot)4078-4082
Aantal pagina's5
TijdschriftAngewandte Chemie - International Edition
Volume57
Nummer van het tijdschrift15
DOI's
StatusGepubliceerd - 3 apr 2018

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