Retinal vascular tortuosity in schizophrenia and bipolar disorder

Abhishek Appaji, Bhargavi Nagendra, Dona Maria Chako, Ananth Padmanabha, Arpitha Jacob, Chaitra V. Hiremath, Shivarama Varambally, Muralidharan Kesavan, Ganesan Venkatasubramanian, Shyam Vasudeva Rao, Carroll A.B. Webers, Tos T.J.M. Berendschot, Naren P. Rao (Corresponding author)

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The micro-vasculature of retina and brain share common morphological, physiological, and pathological properties. Retina being easily accessible, retinal vascular examination provides an indirect assessment of cerebral vasculature. Considering the high prevalence of vascular morbidity in SCZ and BD a few studies have examined retinal vascular caliber and have reported increased retinal venular caliber in schizophrenia (SCZ). Retinal vascular tortuosity could serve as a better structural measure than caliber as it is static and less susceptible to pulse period variations. However, to date, no study has examined retinal vascular tortuosity in SCZ and bipolar disorder (BD). Hence, we examined retinal vascular tortuosity in comparison with healthy volunteers (HV). We included 255 subjects (78 HV, 79 SCZ, and 86 BD) in the age range of 18 to 50 years. Trained personnel acquired images using a non-mydriatic fundus camera. To measure the average retinal arteriolar tortuosity index (RATI) and retinal venular tortuosity index (RVTI), we used a previously validated, semi-automatic algorithm. The results showed significant differences across the three groups in RATI but not in RVTI; both BD and SCZ had significantly increased RATI compared to HV. There was also a significant difference between SCZ and BD, with BD having higher RATI. If shown to be of predictive utility in future longitudinal studies, it has the potential to identify patients at risk of development of adverse vascular events. As retinal vascular imaging is non-invasive and inexpensive, it could serve as a proxy marker and window to cerebral vasculature.

TaalEngels
Pagina's26-32
Aantal pagina's7
TijdschriftSchizophrenia Research
Volume212
DOI's
StatusGepubliceerd - 1 okt 2019

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    Appaji, A., Nagendra, B., Chako, D. M., Padmanabha, A., Jacob, A., Hiremath, C. V., ... Rao, N. P. (2019). Retinal vascular tortuosity in schizophrenia and bipolar disorder. Schizophrenia Research, 212, 26-32. DOI: 10.1016/j.schres.2019.08.020
    Appaji, Abhishek ; Nagendra, Bhargavi ; Chako, Dona Maria ; Padmanabha, Ananth ; Jacob, Arpitha ; Hiremath, Chaitra V. ; Varambally, Shivarama ; Kesavan, Muralidharan ; Venkatasubramanian, Ganesan ; Rao, Shyam Vasudeva ; Webers, Carroll A.B. ; Berendschot, Tos T.J.M. ; Rao, Naren P./ Retinal vascular tortuosity in schizophrenia and bipolar disorder. In: Schizophrenia Research. 2019 ; Vol. 212. blz. 26-32
    @article{a12d0ef4439f4d0ba1c6e6b815bae2df,
    title = "Retinal vascular tortuosity in schizophrenia and bipolar disorder",
    abstract = "The micro-vasculature of retina and brain share common morphological, physiological, and pathological properties. Retina being easily accessible, retinal vascular examination provides an indirect assessment of cerebral vasculature. Considering the high prevalence of vascular morbidity in SCZ and BD a few studies have examined retinal vascular caliber and have reported increased retinal venular caliber in schizophrenia (SCZ). Retinal vascular tortuosity could serve as a better structural measure than caliber as it is static and less susceptible to pulse period variations. However, to date, no study has examined retinal vascular tortuosity in SCZ and bipolar disorder (BD). Hence, we examined retinal vascular tortuosity in comparison with healthy volunteers (HV). We included 255 subjects (78 HV, 79 SCZ, and 86 BD) in the age range of 18 to 50 years. Trained personnel acquired images using a non-mydriatic fundus camera. To measure the average retinal arteriolar tortuosity index (RATI) and retinal venular tortuosity index (RVTI), we used a previously validated, semi-automatic algorithm. The results showed significant differences across the three groups in RATI but not in RVTI; both BD and SCZ had significantly increased RATI compared to HV. There was also a significant difference between SCZ and BD, with BD having higher RATI. If shown to be of predictive utility in future longitudinal studies, it has the potential to identify patients at risk of development of adverse vascular events. As retinal vascular imaging is non-invasive and inexpensive, it could serve as a proxy marker and window to cerebral vasculature.",
    keywords = "Retinal vascular tortuosity, Fundus, Schizophrenia, Bipolar disorder, Psychoses, Cerebrovascular",
    author = "Abhishek Appaji and Bhargavi Nagendra and Chako, {Dona Maria} and Ananth Padmanabha and Arpitha Jacob and Hiremath, {Chaitra V.} and Shivarama Varambally and Muralidharan Kesavan and Ganesan Venkatasubramanian and Rao, {Shyam Vasudeva} and Webers, {Carroll A.B.} and Berendschot, {Tos T.J.M.} and Rao, {Naren P.}",
    year = "2019",
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    doi = "10.1016/j.schres.2019.08.020",
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    journal = "Schizophrenia Research",
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    Appaji, A, Nagendra, B, Chako, DM, Padmanabha, A, Jacob, A, Hiremath, CV, Varambally, S, Kesavan, M, Venkatasubramanian, G, Rao, SV, Webers, CAB, Berendschot, TTJM & Rao, NP 2019, 'Retinal vascular tortuosity in schizophrenia and bipolar disorder' Schizophrenia Research, vol. 212, blz. 26-32. DOI: 10.1016/j.schres.2019.08.020

    Retinal vascular tortuosity in schizophrenia and bipolar disorder. / Appaji, Abhishek; Nagendra, Bhargavi; Chako, Dona Maria; Padmanabha, Ananth; Jacob, Arpitha; Hiremath, Chaitra V.; Varambally, Shivarama; Kesavan, Muralidharan; Venkatasubramanian, Ganesan; Rao, Shyam Vasudeva; Webers, Carroll A.B.; Berendschot, Tos T.J.M.; Rao, Naren P. (Corresponding author).

    In: Schizophrenia Research, Vol. 212, 01.10.2019, blz. 26-32.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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    T1 - Retinal vascular tortuosity in schizophrenia and bipolar disorder

    AU - Appaji,Abhishek

    AU - Nagendra,Bhargavi

    AU - Chako,Dona Maria

    AU - Padmanabha,Ananth

    AU - Jacob,Arpitha

    AU - Hiremath,Chaitra V.

    AU - Varambally,Shivarama

    AU - Kesavan,Muralidharan

    AU - Venkatasubramanian,Ganesan

    AU - Rao,Shyam Vasudeva

    AU - Webers,Carroll A.B.

    AU - Berendschot,Tos T.J.M.

    AU - Rao,Naren P.

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    N2 - The micro-vasculature of retina and brain share common morphological, physiological, and pathological properties. Retina being easily accessible, retinal vascular examination provides an indirect assessment of cerebral vasculature. Considering the high prevalence of vascular morbidity in SCZ and BD a few studies have examined retinal vascular caliber and have reported increased retinal venular caliber in schizophrenia (SCZ). Retinal vascular tortuosity could serve as a better structural measure than caliber as it is static and less susceptible to pulse period variations. However, to date, no study has examined retinal vascular tortuosity in SCZ and bipolar disorder (BD). Hence, we examined retinal vascular tortuosity in comparison with healthy volunteers (HV). We included 255 subjects (78 HV, 79 SCZ, and 86 BD) in the age range of 18 to 50 years. Trained personnel acquired images using a non-mydriatic fundus camera. To measure the average retinal arteriolar tortuosity index (RATI) and retinal venular tortuosity index (RVTI), we used a previously validated, semi-automatic algorithm. The results showed significant differences across the three groups in RATI but not in RVTI; both BD and SCZ had significantly increased RATI compared to HV. There was also a significant difference between SCZ and BD, with BD having higher RATI. If shown to be of predictive utility in future longitudinal studies, it has the potential to identify patients at risk of development of adverse vascular events. As retinal vascular imaging is non-invasive and inexpensive, it could serve as a proxy marker and window to cerebral vasculature.

    AB - The micro-vasculature of retina and brain share common morphological, physiological, and pathological properties. Retina being easily accessible, retinal vascular examination provides an indirect assessment of cerebral vasculature. Considering the high prevalence of vascular morbidity in SCZ and BD a few studies have examined retinal vascular caliber and have reported increased retinal venular caliber in schizophrenia (SCZ). Retinal vascular tortuosity could serve as a better structural measure than caliber as it is static and less susceptible to pulse period variations. However, to date, no study has examined retinal vascular tortuosity in SCZ and bipolar disorder (BD). Hence, we examined retinal vascular tortuosity in comparison with healthy volunteers (HV). We included 255 subjects (78 HV, 79 SCZ, and 86 BD) in the age range of 18 to 50 years. Trained personnel acquired images using a non-mydriatic fundus camera. To measure the average retinal arteriolar tortuosity index (RATI) and retinal venular tortuosity index (RVTI), we used a previously validated, semi-automatic algorithm. The results showed significant differences across the three groups in RATI but not in RVTI; both BD and SCZ had significantly increased RATI compared to HV. There was also a significant difference between SCZ and BD, with BD having higher RATI. If shown to be of predictive utility in future longitudinal studies, it has the potential to identify patients at risk of development of adverse vascular events. As retinal vascular imaging is non-invasive and inexpensive, it could serve as a proxy marker and window to cerebral vasculature.

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    KW - Fundus

    KW - Schizophrenia

    KW - Bipolar disorder

    KW - Psychoses

    KW - Cerebrovascular

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    Appaji A, Nagendra B, Chako DM, Padmanabha A, Jacob A, Hiremath CV et al. Retinal vascular tortuosity in schizophrenia and bipolar disorder. Schizophrenia Research. 2019 okt 1;212:26-32. Beschikbaar vanaf, DOI: 10.1016/j.schres.2019.08.020