Retinal oximetry in normal and amblyopic children: a pilot study

Ashwin Mohan, Vasudha Kemmanu (Corresponding author), Swathi Baliga, Minal Patil, Bhanumathi Madhavrao, Carroll A.B. Webers, Naresh Kumar Yadav, Rohit Shetty, Tos T.J.M. Berendschot

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Purpose: To study the retinal vascular oxygen saturation in amblyopic eyes and compare them to unaffected fellow eyes and eyes of normal subjects. Methods: A total of 32 amblyopic, 24 normal and 13 fellow eyes of patients below age of 18 were enrolled in this prospective observation study. Retinal oximetry was performed using the Oxymap T1 retinal oximeter. Retinal vascular oxygen saturations and diameters were compared between amblyopic eyes, normal eyes and unaffected fellow eyes. Results: The average age was 8.6 years in the amblyopia group (M:F 16:16) and 10.9 years in the normal group (M:F 7:5; p = 0.024). Median corrected distance visual acuity in the amblyopia group was 20/50; it was 20/20 in the other groups (p < 0.001). The average arteriolar and venous saturation in the amblyopia, normal and fellow group was 84.5% (95% CI: 82.6–86.4), 83.2% (95% CI: 80.7–85.6) and 80.8% (95% CI: 78.6–82.9) and 51.9% (95% CI: 50.4–53.4), 50.8% (95% CI: 48.2–53.4) and 49.3% (95% CI: 45.7–52.9). There was no statistically significant difference between the saturation values of the amblyopia group and the controls, however, significantly higher values were found in the amblyopia group compared to the fellow group for arteriolar and venous saturations (p = 0.013; p = 0.005). Arteriolar and venous diameters showed no significant difference between groups. Conclusion: Amblyopic eyes showed higher mean oxygen saturations than the fellow eyes. This observation could be due to altered neuronal activity or could be due to a measurement artefact due to alterations in retinal reflectivity.

TaalEngels
Pagina's684-687
Aantal pagina's4
TijdschriftActa Ophthalmologica
Volume97
Nummer van het tijdschrift7
DOI's
StatusGepubliceerd - 1 nov 2019

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    Mohan, A., Kemmanu, V., Baliga, S., Patil, M., Madhavrao, B., Webers, C. A. B., ... Berendschot, T. T. J. M. (2019). Retinal oximetry in normal and amblyopic children: a pilot study. Acta Ophthalmologica, 97(7), 684-687. DOI: 10.1111/aos.14075
    Mohan, Ashwin ; Kemmanu, Vasudha ; Baliga, Swathi ; Patil, Minal ; Madhavrao, Bhanumathi ; Webers, Carroll A.B. ; Yadav, Naresh Kumar ; Shetty, Rohit ; Berendschot, Tos T.J.M./ Retinal oximetry in normal and amblyopic children : a pilot study. In: Acta Ophthalmologica. 2019 ; Vol. 97, Nr. 7. blz. 684-687
    @article{8b098d84c987482485209093afee09f7,
    title = "Retinal oximetry in normal and amblyopic children: a pilot study",
    abstract = "Purpose: To study the retinal vascular oxygen saturation in amblyopic eyes and compare them to unaffected fellow eyes and eyes of normal subjects. Methods: A total of 32 amblyopic, 24 normal and 13 fellow eyes of patients below age of 18 were enrolled in this prospective observation study. Retinal oximetry was performed using the Oxymap T1 retinal oximeter. Retinal vascular oxygen saturations and diameters were compared between amblyopic eyes, normal eyes and unaffected fellow eyes. Results: The average age was 8.6 years in the amblyopia group (M:F 16:16) and 10.9 years in the normal group (M:F 7:5; p = 0.024). Median corrected distance visual acuity in the amblyopia group was 20/50; it was 20/20 in the other groups (p < 0.001). The average arteriolar and venous saturation in the amblyopia, normal and fellow group was 84.5{\%} (95{\%} CI: 82.6–86.4), 83.2{\%} (95{\%} CI: 80.7–85.6) and 80.8{\%} (95{\%} CI: 78.6–82.9) and 51.9{\%} (95{\%} CI: 50.4–53.4), 50.8{\%} (95{\%} CI: 48.2–53.4) and 49.3{\%} (95{\%} CI: 45.7–52.9). There was no statistically significant difference between the saturation values of the amblyopia group and the controls, however, significantly higher values were found in the amblyopia group compared to the fellow group for arteriolar and venous saturations (p = 0.013; p = 0.005). Arteriolar and venous diameters showed no significant difference between groups. Conclusion: Amblyopic eyes showed higher mean oxygen saturations than the fellow eyes. This observation could be due to altered neuronal activity or could be due to a measurement artefact due to alterations in retinal reflectivity.",
    keywords = "amblyopia, retinal oximetry",
    author = "Ashwin Mohan and Vasudha Kemmanu and Swathi Baliga and Minal Patil and Bhanumathi Madhavrao and Webers, {Carroll A.B.} and Yadav, {Naresh Kumar} and Rohit Shetty and Berendschot, {Tos T.J.M.}",
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    Mohan, A, Kemmanu, V, Baliga, S, Patil, M, Madhavrao, B, Webers, CAB, Yadav, NK, Shetty, R & Berendschot, TTJM 2019, 'Retinal oximetry in normal and amblyopic children: a pilot study' Acta Ophthalmologica, vol. 97, nr. 7, blz. 684-687. DOI: 10.1111/aos.14075

    Retinal oximetry in normal and amblyopic children : a pilot study. / Mohan, Ashwin; Kemmanu, Vasudha (Corresponding author); Baliga, Swathi; Patil, Minal; Madhavrao, Bhanumathi; Webers, Carroll A.B.; Yadav, Naresh Kumar; Shetty, Rohit; Berendschot, Tos T.J.M.

    In: Acta Ophthalmologica, Vol. 97, Nr. 7, 01.11.2019, blz. 684-687.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    TY - JOUR

    T1 - Retinal oximetry in normal and amblyopic children

    T2 - Acta Ophthalmologica

    AU - Mohan,Ashwin

    AU - Kemmanu,Vasudha

    AU - Baliga,Swathi

    AU - Patil,Minal

    AU - Madhavrao,Bhanumathi

    AU - Webers,Carroll A.B.

    AU - Yadav,Naresh Kumar

    AU - Shetty,Rohit

    AU - Berendschot,Tos T.J.M.

    PY - 2019/11/1

    Y1 - 2019/11/1

    N2 - Purpose: To study the retinal vascular oxygen saturation in amblyopic eyes and compare them to unaffected fellow eyes and eyes of normal subjects. Methods: A total of 32 amblyopic, 24 normal and 13 fellow eyes of patients below age of 18 were enrolled in this prospective observation study. Retinal oximetry was performed using the Oxymap T1 retinal oximeter. Retinal vascular oxygen saturations and diameters were compared between amblyopic eyes, normal eyes and unaffected fellow eyes. Results: The average age was 8.6 years in the amblyopia group (M:F 16:16) and 10.9 years in the normal group (M:F 7:5; p = 0.024). Median corrected distance visual acuity in the amblyopia group was 20/50; it was 20/20 in the other groups (p < 0.001). The average arteriolar and venous saturation in the amblyopia, normal and fellow group was 84.5% (95% CI: 82.6–86.4), 83.2% (95% CI: 80.7–85.6) and 80.8% (95% CI: 78.6–82.9) and 51.9% (95% CI: 50.4–53.4), 50.8% (95% CI: 48.2–53.4) and 49.3% (95% CI: 45.7–52.9). There was no statistically significant difference between the saturation values of the amblyopia group and the controls, however, significantly higher values were found in the amblyopia group compared to the fellow group for arteriolar and venous saturations (p = 0.013; p = 0.005). Arteriolar and venous diameters showed no significant difference between groups. Conclusion: Amblyopic eyes showed higher mean oxygen saturations than the fellow eyes. This observation could be due to altered neuronal activity or could be due to a measurement artefact due to alterations in retinal reflectivity.

    AB - Purpose: To study the retinal vascular oxygen saturation in amblyopic eyes and compare them to unaffected fellow eyes and eyes of normal subjects. Methods: A total of 32 amblyopic, 24 normal and 13 fellow eyes of patients below age of 18 were enrolled in this prospective observation study. Retinal oximetry was performed using the Oxymap T1 retinal oximeter. Retinal vascular oxygen saturations and diameters were compared between amblyopic eyes, normal eyes and unaffected fellow eyes. Results: The average age was 8.6 years in the amblyopia group (M:F 16:16) and 10.9 years in the normal group (M:F 7:5; p = 0.024). Median corrected distance visual acuity in the amblyopia group was 20/50; it was 20/20 in the other groups (p < 0.001). The average arteriolar and venous saturation in the amblyopia, normal and fellow group was 84.5% (95% CI: 82.6–86.4), 83.2% (95% CI: 80.7–85.6) and 80.8% (95% CI: 78.6–82.9) and 51.9% (95% CI: 50.4–53.4), 50.8% (95% CI: 48.2–53.4) and 49.3% (95% CI: 45.7–52.9). There was no statistically significant difference between the saturation values of the amblyopia group and the controls, however, significantly higher values were found in the amblyopia group compared to the fellow group for arteriolar and venous saturations (p = 0.013; p = 0.005). Arteriolar and venous diameters showed no significant difference between groups. Conclusion: Amblyopic eyes showed higher mean oxygen saturations than the fellow eyes. This observation could be due to altered neuronal activity or could be due to a measurement artefact due to alterations in retinal reflectivity.

    KW - amblyopia

    KW - retinal oximetry

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    U2 - 10.1111/aos.14075

    DO - 10.1111/aos.14075

    M3 - Article

    VL - 97

    SP - 684

    EP - 687

    JO - Acta Ophthalmologica

    JF - Acta Ophthalmologica

    SN - 1755-375X

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    Mohan A, Kemmanu V, Baliga S, Patil M, Madhavrao B, Webers CAB et al. Retinal oximetry in normal and amblyopic children: a pilot study. Acta Ophthalmologica. 2019 nov 1;97(7):684-687. Beschikbaar vanaf, DOI: 10.1111/aos.14075