TY - JOUR
T1 - Reactions of polypeptide esters in the solid state I : migration of methyl groups
AU - Sluyterman, L.A.A.E.
AU - Veenendaal, H.J.
PY - 1952
Y1 - 1952
N2 - When tetraglycine methyl ester is heated at 100° C a decrease in methoxyl content is observed, mainly after an induction period of about 200 hours. The reaction is virtually finished after 600 hours. Previous powdering of the ester crystals slightly reduces the induction period. The reaction product mainly consists of a mixture of tetraglycine, N-methyl-glycyl-triglycine (sarcosyl-triglycine) and N-dimethylglycyl-triglycine. When alanyl-triglycine methyl ester is heated at 100° C the induction period extends over several months.
AB - When tetraglycine methyl ester is heated at 100° C a decrease in methoxyl content is observed, mainly after an induction period of about 200 hours. The reaction is virtually finished after 600 hours. Previous powdering of the ester crystals slightly reduces the induction period. The reaction product mainly consists of a mixture of tetraglycine, N-methyl-glycyl-triglycine (sarcosyl-triglycine) and N-dimethylglycyl-triglycine. When alanyl-triglycine methyl ester is heated at 100° C the induction period extends over several months.
U2 - 10.1002/recl.19520710205
DO - 10.1002/recl.19520710205
M3 - Article
SN - 0165-0513
VL - 71
SP - 137
EP - 152
JO - Recueil des Travaux Chimiques des Pays-Bas
JF - Recueil des Travaux Chimiques des Pays-Bas
ER -