RAFT Emulsion Polymerization as a Platform to Generate Well-Defined Biocompatible Latex Nanoparticles

Pratik Gurnani, Carlos Sanchez-Cano, Kristin Abraham, Helena Xandri-Monje, Alexander B. Cook, Matthias Hartlieb, Francis Lévi, Robert Dallmann, Sébastien Perrier

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

19 Citaten (Scopus)

Samenvatting

Current approaches to generate core–shell nanoparticles for biomedical applications are limited by factors such as synthetic scalability and circulatory desorption of cytotoxic surfactants. Developments in controlled radical polymerization, particularly in dispersed states, represent a promising method of overcoming these challenges. In this work, well-defined PEGylated nanoparticles are synthesized using reversible addition fragmentation chain transfer emulsion polymerization to control particle size and surface composition and were further characterized with light scattering, electron microscopy, and size exclusion chromatography. Importantly, the nanoparticles are found to be tolerated both in vitro and in vivo, without the need for any purification after particle synthesis. Pharmacokinetic and biodistribution studies in mice, following intraperitoneal injection of the nanoparticles, reveal a long (>76 h) circulation time and accumulation in the liver.

Originele taal-2Engels
Artikelnummer1800213
TijdschriftMacromolecular Bioscience
Volume18
Nummer van het tijdschrift10
DOI's
StatusGepubliceerd - okt. 2018
Extern gepubliceerdJa

Bibliografische nota

Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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