Quantitative CT based radiomics as predictor of resectability of pancreatic adenocarcinoma

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

4 Citaten (Scopus)
1 Downloads (Pure)


In current clinical practice, the resectability of pancreatic ductal adenocarcinoma (PDA) is determined subjec-tively by a physician, which is an error-prone procedure. In this paper, we present a method for automated determination of resectability of PDA from a routine abdominal CT, to reduce such decision errors. The tumor features are extracted from a group of patients with both hypo- A nd iso-attenuating tumors, of which 29 were resectable and 21 were not. The tumor contours are supplied by a medical expert. We present an approach that uses intensity, shape, and texture features to determine tumor resectability. The best classification results are obtained with fine Gaussian SVM and the L0 Feature Selection algorithms. Compared to expert predictions made on the same dataset, our method achieves better classification results. We obtain significantly better results on correctly predicting non-resectability (+17%) compared to a expert, which is essential for patient treatment (negative prediction value). Moreover, our predictions of resectability exceed expert predictions by approximately 3% (positive prediction value).

Originele taal-2Engels
TitelSPIE.Medical Imaging: Computer-Aided Diagnosis, 10-15 February 2018, Houston, Texas
SubtitelComputer-Aided Diagnosis
Plaats van productieBellingham
ISBN van elektronische versie9781510616394
StatusGepubliceerd - 1 jan. 2018
EvenementSPIE Medical Imaging 2018 - Houston, Verenigde Staten van Amerika
Duur: 10 feb. 201815 feb. 2018

Publicatie series

NaamProceedings of SPIE


CongresSPIE Medical Imaging 2018
Land/RegioVerenigde Staten van Amerika

Bibliografische nota

session PS9


Duik in de onderzoeksthema's van 'Quantitative CT based radiomics as predictor of resectability of pancreatic adenocarcinoma'. Samen vormen ze een unieke vingerafdruk.

Citeer dit