Quantitative ultrasound molecular imaging for antiangiogenic therapy monitoring

S. Turco, A. El Kaffas, J. Zhou, H. Wijkstra, J.K. Willmann, M. Mischi

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

  • 2 Citaties

Uittreksel

The link between cancer growth and angiogenesis has led to the development of new techniques for cancer imaging and therapy. Ultrasound molecular imaging permits the visualization of angiogenesis by use of novel targeted ultrasound contrast agents, (tUCA), consisting of ligand-bearing microbubbles designed to specifically bind molecular angiogenic expressions. Discrimination between bound and free microbubbles is crucial to quantify angiogenesis. Currently, the degree of binding is assessed by the differential targeted enhancement, requiring the application of a destructive burst in the late phase (usually 5-10 min after injection) to isolate the signal from bound microbubbles. Recently, we proposed a novel method for quantitative assessment of binding by modeling the microbubble binding kinetics during the tUCA first pass, reducing the acquisition time to 1 min with no need for a destructive burst. The feasibility of the method for angiogenesis imaging was shown in prostate tumor-bearing rats. In this work, we evaluate the proposed method for monitoring the response to angiogenic treatment in human colon cancer xenograft-bearing mice.
TaalEngels
TitelUltrasonics Symposium (IUS), 2016 IEEE International
UitgeverijInstitute of Electrical and Electronics Engineers (IEEE)
Pagina's1-4
Aantal pagina's4
ISBN van elektronische versie978-1-4673-9897-8
DOI's
StatusGepubliceerd - 3 nov 2016
Evenement2016 IEEE International Ultrasonics Symposium (IUS 2016) - Convention Center Vinci, Tours, Frankrijk
Duur: 18 sep 201621 sep 2016
http://sites.ieee.org/ius-2016/

Congres

Congres2016 IEEE International Ultrasonics Symposium (IUS 2016)
Verkorte titelIUS 2016
LandFrankrijk
StadTours
Periode18/09/1621/09/16
Internet adres

Vingerafdruk

Microbubbles
Molecular Imaging
Ultrasonography
Contrast Media
Neoplasms
Therapeutics
Heterografts
Colonic Neoplasms
Prostate
Ligands
Injections
Growth

Citeer dit

Turco, S., El Kaffas, A., Zhou, J., Wijkstra, H., Willmann, J. K., & Mischi, M. (2016). Quantitative ultrasound molecular imaging for antiangiogenic therapy monitoring. In Ultrasonics Symposium (IUS), 2016 IEEE International (blz. 1-4). Institute of Electrical and Electronics Engineers (IEEE). DOI: 10.1109/ULTSYM.2016.7728653
Turco, S. ; El Kaffas, A. ; Zhou, J. ; Wijkstra, H. ; Willmann, J.K. ; Mischi, M./ Quantitative ultrasound molecular imaging for antiangiogenic therapy monitoring. Ultrasonics Symposium (IUS), 2016 IEEE International. Institute of Electrical and Electronics Engineers (IEEE), 2016. blz. 1-4
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Turco, S, El Kaffas, A, Zhou, J, Wijkstra, H, Willmann, JK & Mischi, M 2016, Quantitative ultrasound molecular imaging for antiangiogenic therapy monitoring. in Ultrasonics Symposium (IUS), 2016 IEEE International. Institute of Electrical and Electronics Engineers (IEEE), blz. 1-4, Tours, Frankrijk, 18/09/16. DOI: 10.1109/ULTSYM.2016.7728653

Quantitative ultrasound molecular imaging for antiangiogenic therapy monitoring. / Turco, S.; El Kaffas, A.; Zhou, J.; Wijkstra, H.; Willmann, J.K.; Mischi, M.

Ultrasonics Symposium (IUS), 2016 IEEE International. Institute of Electrical and Electronics Engineers (IEEE), 2016. blz. 1-4.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

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AU - El Kaffas,A.

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AB - The link between cancer growth and angiogenesis has led to the development of new techniques for cancer imaging and therapy. Ultrasound molecular imaging permits the visualization of angiogenesis by use of novel targeted ultrasound contrast agents, (tUCA), consisting of ligand-bearing microbubbles designed to specifically bind molecular angiogenic expressions. Discrimination between bound and free microbubbles is crucial to quantify angiogenesis. Currently, the degree of binding is assessed by the differential targeted enhancement, requiring the application of a destructive burst in the late phase (usually 5-10 min after injection) to isolate the signal from bound microbubbles. Recently, we proposed a novel method for quantitative assessment of binding by modeling the microbubble binding kinetics during the tUCA first pass, reducing the acquisition time to 1 min with no need for a destructive burst. The feasibility of the method for angiogenesis imaging was shown in prostate tumor-bearing rats. In this work, we evaluate the proposed method for monitoring the response to angiogenic treatment in human colon cancer xenograft-bearing mice.

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Turco S, El Kaffas A, Zhou J, Wijkstra H, Willmann JK, Mischi M. Quantitative ultrasound molecular imaging for antiangiogenic therapy monitoring. In Ultrasonics Symposium (IUS), 2016 IEEE International. Institute of Electrical and Electronics Engineers (IEEE). 2016. blz. 1-4. Beschikbaar vanaf, DOI: 10.1109/ULTSYM.2016.7728653