Quantification of PSMA expression in prostate cancer by pharmacokinetic modeling of targeted ultrasound nanobubbles

S. Turco, R.H. Perera, H. Wijkstra, A.A. Exner, M. Mischi

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Samenvatting

The value of contrast-enhanced ultrasound (CEUS) for prostate cancer diagnostics is still debated. Novel targeted ultrasound contrast agents enable visualization of molecular and cellular processes in vivo and non-invasively. Microbubbles targeted to the vascular endothelial growth factor receptor 2 have been successfully tested in humans, but detection rate for prostate cancer was limited to 65%. While microbubbles can only target molecules in the blood vessels, novel nanobubbles (NBs) can extravasate, thus enabling reaching targets beyond the vessel wall. Recently, NBs targeted to the prostate specific membrane antigen (PSMA), which is overexpressed by prostate cancer cells, have shown selective accumulation in prostate-tumor mouse models. However, methods for quantification of NB binding are still lacking. In this work, we propose a pharmacokinetic modeling approach to estimate the binding potential of PSMA-targeted NBs, and we test the proposed method in 7 dual-tumor mouse models of prostate cancer.
Originele taal-2Engels
Titel2019 IEEE International Ultrasonics Symposium, IUS 2019
Plaats van productiePiscataway
UitgeverijInstitute of Electrical and Electronics Engineers
Pagina's399-402
Aantal pagina's4
ISBN van elektronische versie978-1-7281-4596-9
DOI's
StatusGepubliceerd - 2019
Evenement2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, Verenigd Koninkrijk
Duur: 6 okt 20199 okt 2019

Congres

Congres2019 IEEE International Ultrasonics Symposium, IUS 2019
LandVerenigd Koninkrijk
StadGlasgow
Periode6/10/199/10/19

Vingerafdruk Duik in de onderzoeksthema's van 'Quantification of PSMA expression in prostate cancer by pharmacokinetic modeling of targeted ultrasound nanobubbles'. Samen vormen ze een unieke vingerafdruk.

  • Citeer dit

    Turco, S., Perera, R. H., Wijkstra, H., Exner, A. A., & Mischi, M. (2019). Quantification of PSMA expression in prostate cancer by pharmacokinetic modeling of targeted ultrasound nanobubbles. In 2019 IEEE International Ultrasonics Symposium, IUS 2019 (blz. 399-402). [8925563] Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/ULTSYM.2019.8925563