Pretargeting kit, method and agents used therein

Marc S. Robillard (Uitvinder), Raffaella Rossin (Uitvinder), Johan Lub (Uitvinder), Pascal R. Verkerk (Uitvinder), Dirk Burdinski (Uitvinder)

Onderzoeksoutput: OctrooiOctrooi-publicatie

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Samenvatting

Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an alkene or alkyne dienohile.

Originele taal-2Engels
OctrooinummerWO2010119382
IPCA61K 51/ 10 A I
Prioriteitsdatum29/10/09
StatusGepubliceerd - 21 okt. 2010
Extern gepubliceerdJa

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