Samenvatting
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an alkene or alkyne dienohile.
Originele taal-2 | Engels |
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Octrooinummer | WO2010119382 |
IPC | A61K 51/ 10 A I |
Prioriteitsdatum | 29/10/09 |
Status | Gepubliceerd - 21 okt. 2010 |
Extern gepubliceerd | Ja |