Pretargeting kit, method and agents used therein

Johan Lub; Wolter ten Hoeve; Raffaella Rossin; Sandra M. van den Bosch; Marc Stefan Robillard

Pretargeting kit, method and agents used therein

Johan Lub (Uitvinder)
, Wolter ten Hoeve (Uitvinder)
, Raffaella Rossin (Uitvinder)
, Sandra M. van den Bosch (Uitvinder)
, Marc Stefan Robillard (Uitvinder)

Onderzoeksoutput: Octrooi › Octrooi-publicatie

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Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistryin providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.

Originele taal-2	Engels
Octrooinummer	WO2012049624
IPC	A61K 51/ 04 A I
Prioriteitsdatum	14/10/10
Status	Gepubliceerd - 19 apr. 2012
Extern gepubliceerd	Ja

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WO2012049624A1Definitieve gepubliceerde versie, 4,89 MB

https://nl.espacenet.com/publicationDetails/biblio?II=0&ND=3&adjacent=true&locale=nl_NL&FT=D&date=20120419&CC=WO&NR=2012049624A1&KC=A1#

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title = "Pretargeting kit, method and agents used therein",

abstract = "Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistryin providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.",

author = "Johan Lub and \{ten Hoeve\}, Wolter and Raffaella Rossin and \{van den Bosch\}, \{Sandra M.\} and Robillard, \{Marc Stefan\}",

year = "2012",

month = apr,

day = "19",

language = "English",

type = "Patent",

note = "WO2012049624; A61K 51/ 04 A I",

}

TY - PAT

T1 - Pretargeting kit, method and agents used therein

AU - Lub, Johan

AU - ten Hoeve, Wolter

AU - Rossin, Raffaella

AU - van den Bosch, Sandra M.

AU - Robillard, Marc Stefan

PY - 2012/4/19

Y1 - 2012/4/19

N2 - Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistryin providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.

AB - Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistryin providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.

M3 - Patent publication

M1 - WO2012049624

ER -

Pretargeting kit, method and agents used therein

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