Pretargeting kit, method and agents used therein

Marc S. Robillard; Raffaella Rossin; Johan Lub; Pascal R. Verkerk; Dirk Burdinski

Pretargeting kit, method and agents used therein

Marc S. Robillard (Uitvinder), Raffaella Rossin (Uitvinder), Johan Lub (Uitvinder), Pascal R. Verkerk (Uitvinder), Dirk Burdinski (Uitvinder)

Onderzoeksoutput: Octrooi › Octrooi-publicatie

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Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other a cyclooctene or cyclooctyne.

Originele taal-2	Engels
Octrooinummer	US2012034161
IPC	C07K 16/ 18 A I
Prioriteitsdatum	12/04/10
Status	Gepubliceerd - 9 feb. 2012

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US2012034161A1Definitieve gepubliceerde versie, 1,85 MB

https://nl.espacenet.com/publicationDetails/biblio?II=0&ND=3&adjacent=true&locale=nl_NL&FT=D&date=20120209&CC=US&NR=2012034161A1&KC=A1#

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title = "Pretargeting kit, method and agents used therein",

abstract = "Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other a cyclooctene or cyclooctyne.",

author = "Robillard, {Marc S.} and Raffaella Rossin and Johan Lub and Verkerk, {Pascal R.} and Dirk Burdinski",

year = "2012",

month = feb,

day = "9",

language = "English",

type = "Patent",

note = "US2012034161; C07K 16/ 18 A I",

}

TY - PAT

T1 - Pretargeting kit, method and agents used therein

AU - Robillard, Marc S.

AU - Rossin, Raffaella

AU - Lub, Johan

AU - Verkerk, Pascal R.

AU - Burdinski, Dirk

PY - 2012/2/9

Y1 - 2012/2/9

N2 - Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other a cyclooctene or cyclooctyne.

AB - Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other a cyclooctene or cyclooctyne.

M3 - Patent publication

M1 - US2012034161

ER -

Pretargeting kit, method and agents used therein

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