Pretargeting kit, method and agents used therein

Marc S. Robillard (Uitvinder), Raffaella Rossin (Uitvinder), Johan Lub (Uitvinder), Pascal R. Verkerk (Uitvinder), Dirk Burdinski (Uitvinder)

    Onderzoeksoutput: OctrooiOctrooi-publicatie

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    Samenvatting

    Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other a cyclooctene or cyclooctyne.

    Originele taal-2Engels
    OctrooinummerUS2012034161
    IPCC07K 16/ 18 A I
    Prioriteitsdatum12/04/10
    StatusGepubliceerd - 9 feb 2012

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