Prehospital risk assessment and direct transfer to a percutaneous coronary intervention centre in suspected acute coronary syndrome

Jesse Demandt, Arjan Koks, Dennis Sagel, Veerle A.E. Van Hattem, Rutger J. Haest, Eric Heijmen, H. Thijssen, Luuk C. Otterspoor, Dennis Van Veghel, Rob Eerdekens, Mohamed El Farissi, Koen Teeuwen, Inge Wijnbergen, Pim van der Harst, Nico H.J. Pijls, Marcel van 't Veer, Pim A.L. Tonino, Lukas R.C. Dekker, Pieter J. Vlaar (Corresponding author)

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1 Citaat (Scopus)

Samenvatting

Objective: Prehospital risk stratification and triage are currently not performed in patients suspected of non-ST-segment elevation acute coronary syndrome (NSTE-ACS). This may lead to prolonged time to revascularisation, increased duration of hospital admission and higher healthcare costs. The preHEART score (prehospital history, ECG, age, risk factors and point-of-care troponin score) can be used by emergency medical services (EMS) personnel for prehospital risk stratification and triage decisions in patients with NSTE-ACS. The aim of the current study was to evaluate the effect of prehospital risk stratification and direct transfer to a percutaneous coronary intervention (PCI) centre, based on the preHEART score, on time to final invasive diagnostics or culprit revascularisation. Methods: Prospective, multicentre, two-cohort study in patients with suspected NSTE-ACS. The first cohort is observational (standard care), while the second (interventional) cohort includes patients who are stratified for direct transfer to either a PCI or a non-PCI centre based on their preHEART score. Risk stratification and triage are performed by EMS personnel. The primary endpoint of the study is time from first medical contact until final invasive diagnostics or revascularisation. Secondary endpoints are time from first medical contact until intracoronary angiography (ICA), duration of hospital admission, number of invasive diagnostics, number of inter-hospital transfers and major adverse cardiac events at 7 and 30 days. Results: A total of 1069 patients were included. In the interventional cohort (n=577), time between final invasive diagnostics or revascularisation (42 (17-101) hours vs 20 (5-44) hours, p& lt;0.001) and length of hospital admission (3 (2-5) days vs 2 (1-4) days, p=0.007) were shorter than in the observational cohort (n=492). In patients with NSTE-ACS in need for ICA or revascularisation, healthcare costs were reduced in the interventional cohort (& euro;5599 (2978-9625) vs & euro;4899 (2278-5947), p=0.02). Conclusion: Prehospital risk stratification and direct transfer to a PCI centre, based on the preHEART score, reduces time from first medical contact to final invasive diagnostics and revascularisation, reduces duration of hospital admission and decreases healthcare costs in patients with NSTE-ACS in need for ICA or revascularisation. Trial registration: NCT05243485. & copy; Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.

Originele taal-2Engels
Artikelnummerheartjnl-2023-323346
Pagina's (van-tot)408-415
Aantal pagina's8
TijdschriftHeart
Volume110
Nummer van het tijdschrift6
DOI's
StatusGepubliceerd - 23 feb. 2024

Financiering

The study is funded by ZonMw, the Dutch Organisation for Health Research and Development, grant program “Topspecialistische Zorg en Onderzoek”, grant number 10070012010001.

FinanciersFinanciernummer
Topspecialistische Zorg en Onderzoek10070012010001
ZonMw : Dutch Organisation for Health Research and Development

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