Polypeptide polymer brushes by light-induced surface polymerization of amino acid N-carboxyanhydrides

T. Stukenkemper, X. Paquez, M.W.G.M. Verhoeven, E.J.M. Hensen, A.A. Dias, D.F. Brougham, A. Heise

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

12 Citaten (Scopus)


Silicon wafers are decorated with photoamine generator 4,5-dimethoxy-2-nitrobenzyl 3-(triethoxysilyl)propyl carbamate. UV-irradiation in the presence of benzyl-l-glutamate N-carboxyanhydride is carried out, resulting in the release of the surface-bound primary amines, making them viable N-carboxyanhydride (NCA) polymerization initiators. Successful polypeptide grafting is confirmed by water contact angle measurements as well as by ellipsometry, revealing a poly(benzyl-l-glutamate) (PBLG) layer of ≈3 nm. X-ray photoelectron spectroscopy confirms the presence of amide groups in the grafted PBLG while time-of-flight secondary ion mass spectroscopy provides additional evidence for the presence of PBLG on the surface. Evaluation of negative control samples confirms successful UV surface grafting. The approach is thus established as a viable general method for light exposure directable polypeptide functionalization of silicon surfaces.

Originele taal-2Engels
Aantal pagina's5
TijdschriftMacromolecular Rapid Communications
Nummer van het tijdschrift7
StatusGepubliceerd - 1 apr. 2018


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