Polypeptide nanoparticles obtained from emulsion polymerization of amino acid N-carboxyanhydrides

Jaco Jacobs, Dražen Pavlović, Hannah Prydderch, Mohammad-Amin Moradi, Emmanuel Ibarboure, Johan P.A. Heuts, Sebastien Lecommandoux, Andreas Heise (Corresponding author)

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Uittreksel

Polypeptide nanoparticles were obtained by the miniemulsion polymerization of S-(o-nitrobenzyl)-l-cysteine (NBC) N-carboxyanhydride (NCA). Through process optimization, reaction conditions were identified that allowed the polymerization of the water sensitive NCA to yield nanoparticles of about 220 nm size. Subsequent UV-irradiation of the nanoparticle emulsions caused the in situ removal of the nitrobenzyl group and particle cross-linking through disulfide bond formation accompanied by the shrinkage of the particles.

TaalEngels
Pagina's12522-12526
Aantal pagina's5
TijdschriftJournal of the American Chemical Society
Volume141
Nummer van het tijdschrift32
DOI's
StatusGepubliceerd - 14 aug 2019

Vingerafdruk

Emulsion polymerization
Polypeptides
Emulsions
Polymerization
Nanoparticles
Amino acids
Amino Acids
Peptides
Disulfides
Cysteine
Irradiation
Water

Citeer dit

Jacobs, Jaco ; Pavlović, Dražen ; Prydderch, Hannah ; Moradi, Mohammad-Amin ; Ibarboure, Emmanuel ; Heuts, Johan P.A. ; Lecommandoux, Sebastien ; Heise, Andreas. / Polypeptide nanoparticles obtained from emulsion polymerization of amino acid N-carboxyanhydrides. In: Journal of the American Chemical Society. 2019 ; Vol. 141, Nr. 32. blz. 12522-12526
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title = "Polypeptide nanoparticles obtained from emulsion polymerization of amino acid N-carboxyanhydrides",
abstract = "Polypeptide nanoparticles were obtained by the miniemulsion polymerization of S-(o-nitrobenzyl)-l-cysteine (NBC) N-carboxyanhydride (NCA). Through process optimization, reaction conditions were identified that allowed the polymerization of the water sensitive NCA to yield nanoparticles of about 220 nm size. Subsequent UV-irradiation of the nanoparticle emulsions caused the in situ removal of the nitrobenzyl group and particle cross-linking through disulfide bond formation accompanied by the shrinkage of the particles.",
author = "Jaco Jacobs and Dražen Pavlović and Hannah Prydderch and Mohammad-Amin Moradi and Emmanuel Ibarboure and Heuts, {Johan P.A.} and Sebastien Lecommandoux and Andreas Heise",
year = "2019",
month = "8",
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doi = "10.1021/jacs.9b06750",
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Jacobs, J, Pavlović, D, Prydderch, H, Moradi, M-A, Ibarboure, E, Heuts, JPA, Lecommandoux, S & Heise, A 2019, 'Polypeptide nanoparticles obtained from emulsion polymerization of amino acid N-carboxyanhydrides' Journal of the American Chemical Society, vol. 141, nr. 32, blz. 12522-12526. DOI: 10.1021/jacs.9b06750

Polypeptide nanoparticles obtained from emulsion polymerization of amino acid N-carboxyanhydrides. / Jacobs, Jaco; Pavlović, Dražen; Prydderch, Hannah; Moradi, Mohammad-Amin; Ibarboure, Emmanuel; Heuts, Johan P.A.; Lecommandoux, Sebastien; Heise, Andreas (Corresponding author).

In: Journal of the American Chemical Society, Vol. 141, Nr. 32, 14.08.2019, blz. 12522-12526.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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AU - Jacobs,Jaco

AU - Pavlović,Dražen

AU - Prydderch,Hannah

AU - Moradi,Mohammad-Amin

AU - Ibarboure,Emmanuel

AU - Heuts,Johan P.A.

AU - Lecommandoux,Sebastien

AU - Heise,Andreas

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N2 - Polypeptide nanoparticles were obtained by the miniemulsion polymerization of S-(o-nitrobenzyl)-l-cysteine (NBC) N-carboxyanhydride (NCA). Through process optimization, reaction conditions were identified that allowed the polymerization of the water sensitive NCA to yield nanoparticles of about 220 nm size. Subsequent UV-irradiation of the nanoparticle emulsions caused the in situ removal of the nitrobenzyl group and particle cross-linking through disulfide bond formation accompanied by the shrinkage of the particles.

AB - Polypeptide nanoparticles were obtained by the miniemulsion polymerization of S-(o-nitrobenzyl)-l-cysteine (NBC) N-carboxyanhydride (NCA). Through process optimization, reaction conditions were identified that allowed the polymerization of the water sensitive NCA to yield nanoparticles of about 220 nm size. Subsequent UV-irradiation of the nanoparticle emulsions caused the in situ removal of the nitrobenzyl group and particle cross-linking through disulfide bond formation accompanied by the shrinkage of the particles.

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DO - 10.1021/jacs.9b06750

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