Polyoxazoline copolymer comprising calcium binding groups

Sander C.G. Leeuwenburgh; Jan Cornelis Maria van Hest; María José Sánchez-Fernández; Rosa Pilar Felix Lanao; Joost Opsteen; Johannes Caspar Mathias Elizabeth Bender

Polyoxazoline copolymer comprising calcium binding groups

Sander C.G. Leeuwenburgh (Uitvinder), Jan Cornelis Maria van Hest (Uitvinder), María José Sánchez-Fernández (Uitvinder), Rosa Pilar Felix Lanao (Uitvinder), Joost Opsteen (Uitvinder), Johannes Caspar Mathias Elizabeth Bender (Uitvinder)

Onderzoeksoutput: Octrooi › Octrooi-publicatie

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The invention relates to a polyoxazoline (POx) copolymer comprising at least 20 oxazoline units, including at least 4 non-terminal oxazoline units that contain a calcium binding group selected from bisphosphonate, citrate, ethylenediaminetetraacetic acid (EDTA) and combinations thereof. The POx copolymers of the present invention exhibit very high affinity for calcium ions and are capable of forming hydrogels due to reversible cross-linking with Ca2+ ions. The POx copolymers offer the important advantage that they are bioresorbable. Calcium affinity, biodegradability and hydrogel characteristics of the POx copolymer can easily be tuned due to the fact that the POx can easily be derivatised along the entire polymeric backbone and not only at the end-groups. The POx copolymers of the invention may suitably be applied in a variety of biomedical applications, such as barrier membranes, patches, meshes, tapes, bone fixation devices, bone implants, (injectable) hydrogels, bone-setting glue and nanoparticles.

Originele taal-2	Engels
Octrooinummer	WO2021018922
IPC	C08G 73/ 00 A I
Prioriteitsdatum	30/07/19
Status	Gepubliceerd - 4 feb. 2021

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WO2021018922A1Definitieve gepubliceerde versie, 1,6 MB

https://nl.espacenet.com/publicationDetails/biblio?FT=D&date=20210204&DB=EPODOC&locale=nl_NL&CC=WO&NR=2021018922A1&KC=A1&ND=4

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title = "Polyoxazoline copolymer comprising calcium binding groups",

abstract = "The invention relates to a polyoxazoline (POx) copolymer comprising at least 20 oxazoline units, including at least 4 non-terminal oxazoline units that contain a calcium binding group selected from bisphosphonate, citrate, ethylenediaminetetraacetic acid (EDTA) and combinations thereof. The POx copolymers of the present invention exhibit very high affinity for calcium ions and are capable of forming hydrogels due to reversible cross-linking with Ca2+ ions. The POx copolymers offer the important advantage that they are bioresorbable. Calcium affinity, biodegradability and hydrogel characteristics of the POx copolymer can easily be tuned due to the fact that the POx can easily be derivatised along the entire polymeric backbone and not only at the end-groups. The POx copolymers of the invention may suitably be applied in a variety of biomedical applications, such as barrier membranes, patches, meshes, tapes, bone fixation devices, bone implants, (injectable) hydrogels, bone-setting glue and nanoparticles.",

author = "Leeuwenburgh, {Sander C.G.} and {van Hest}, {Jan Cornelis Maria} and S{\'a}nchez-Fern{\'a}ndez, {Mar{\'i}a Jos{\'e}} and {Felix Lanao}, {Rosa Pilar} and Joost Opsteen and Bender, {Johannes Caspar Mathias Elizabeth}",

year = "2021",

month = feb,

day = "4",

language = "English",

type = "Patent",

note = "WO2021018922; C08G 73/ 00 A I",

}

TY - PAT

T1 - Polyoxazoline copolymer comprising calcium binding groups

AU - Leeuwenburgh, Sander C.G.

AU - van Hest, Jan Cornelis Maria

AU - Sánchez-Fernández, María José

AU - Felix Lanao, Rosa Pilar

AU - Opsteen, Joost

AU - Bender, Johannes Caspar Mathias Elizabeth

PY - 2021/2/4

Y1 - 2021/2/4

N2 - The invention relates to a polyoxazoline (POx) copolymer comprising at least 20 oxazoline units, including at least 4 non-terminal oxazoline units that contain a calcium binding group selected from bisphosphonate, citrate, ethylenediaminetetraacetic acid (EDTA) and combinations thereof. The POx copolymers of the present invention exhibit very high affinity for calcium ions and are capable of forming hydrogels due to reversible cross-linking with Ca2+ ions. The POx copolymers offer the important advantage that they are bioresorbable. Calcium affinity, biodegradability and hydrogel characteristics of the POx copolymer can easily be tuned due to the fact that the POx can easily be derivatised along the entire polymeric backbone and not only at the end-groups. The POx copolymers of the invention may suitably be applied in a variety of biomedical applications, such as barrier membranes, patches, meshes, tapes, bone fixation devices, bone implants, (injectable) hydrogels, bone-setting glue and nanoparticles.

AB - The invention relates to a polyoxazoline (POx) copolymer comprising at least 20 oxazoline units, including at least 4 non-terminal oxazoline units that contain a calcium binding group selected from bisphosphonate, citrate, ethylenediaminetetraacetic acid (EDTA) and combinations thereof. The POx copolymers of the present invention exhibit very high affinity for calcium ions and are capable of forming hydrogels due to reversible cross-linking with Ca2+ ions. The POx copolymers offer the important advantage that they are bioresorbable. Calcium affinity, biodegradability and hydrogel characteristics of the POx copolymer can easily be tuned due to the fact that the POx can easily be derivatised along the entire polymeric backbone and not only at the end-groups. The POx copolymers of the invention may suitably be applied in a variety of biomedical applications, such as barrier membranes, patches, meshes, tapes, bone fixation devices, bone implants, (injectable) hydrogels, bone-setting glue and nanoparticles.

M3 - Patent publication

M1 - WO2021018922

ER -

Polyoxazoline copolymer comprising calcium binding groups

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