Polynitroxyl functionalized dendrimers as paramagnetic relaxation enhancers : effects of structure on relaxivity

A.J. Maliakal, N.J. Turro, A.W. Bosman, J. Cornel, E.W. Meijer

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Samenvatting

The 1H NMR relaxivity of ortho and para dinitroxide substituted phthalate esters and a series of nitroxyl functionalized poly(propylene imine) dendrimers has been measured in acetonitrile and methanol. Studies of dinitroxide relaxivity indicate that electron exchange rate has only a small effect on relaxivity. In studies on dendritic polynitroxides, the per-nitroxide based relaxivity nearly doubles for the generation 5 nitroxyl functionalized dendrimer as compared to a mononitroxide model. This relaxivity enhancement may be due to crowding of dendrimer surface groups in higher generation dendrimers. Dendritic polynitroxides exhibit high relaxivities, making them exciting candidates for magnetic resonance imaging applications. [on SciFinder (R)]
Originele taal-2Engels
TitelAbstracts of Papers, 226th ACS National Meeting, New York, NY, United States, September 7-11, 2003
Plaats van productieWashington
UitgeverijAmerican Chemical Society
Pagina'sORGN-353
ISBN van geprinte versie0-8412-3889-8
StatusGepubliceerd - 2003
Evenement226th ACS National Meeting - New York, Verenigde Staten van Amerika
Duur: 7 sep 200311 sep 2003

Congres

Congres226th ACS National Meeting
Land/RegioVerenigde Staten van Amerika
StadNew York
Periode7/09/0311/09/03
Ander226th ACS National Meeting, Fall Meeting, New York, NY, United States, September 7-11, 2003

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